MXenes are a family of two-dimensional multifunctional materials in a rapid development phase since their discovery in 2011. MXenes possess excellent features like high conductivity and surface area, improved mechanical properties, hydrophilicity, and ability to tune the surface properties with modifying functional groups. These features make MXenes suitable candidates for a wide range of applications, including biomedical and energy storage. This review is focused on various types of MXenes which are recently reported for sensor applications. The current scenario regarding fabrication and properties of MXenes are initially described, followed by a discussion of their applications as piezoresistive and biochemical sensors. This involves mechanical strain detection and detection of biomolecules, biomarkers, and drug molecules relevant to biomedical applications. Finally, the future perspectives are briefly discussed, which will help the researchers identify the limitations for the current scenario and develop new strategies that focus on developing novel, efficient and sensitive MXene based sensors.