One-step hydrothermal synthesis with in situ milling of biologically relevant hydroxyapatite

Chesley, Mitchell; Kennard, Raymond; Roozbahani, Sahar; Kim, Sumin; Kukk, Kora; Mason, Michael D.

doi:10.1016/j.msec.2020.110962

Cited by 33 publications

(16 citation statements)

References 23 publications

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“…Among the artificial substitutes used for bone defect repair and regeneration, calcium phosphate ceramics are widely regarded as one of the most promising bone substitute materials because their chemical composition is similar to that of bone, and has good biocompatibility, osteoconduction and osteoinduction [ [8] , [9] , [10] , [11] , [12] , [13] ]. Previous studies from our group [ 11 , 14 , 15 ] and other groups [ 16 , 17 ] have shown that the special phase composition and porous structure of osteoinductive CaP ceramics enable it to interact with signal molecules and extracellular matrix in the host system, thus creating a local environment conducive to new bone formation.…”

Section: Introductionmentioning

confidence: 99%

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Zhi

Xiao-hua

Sun

et al. 2022

Bioactive Materials

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So far, how to achieve the optimal regenerative repair of large load-bearing bone defects using artificial bone grafts is a huge challenge in clinic. In this study, a strategy of combining osteoinductive biphasic calcium phosphate (BCP) bioceramic scaffolds with intramedullary nail fixation for creating stable osteogenic microenvironment was applied to repair large segmental bone defects (3.0 cm in length) in goat femur model. The material characterization results showed that the BCP scaffold had the initial compressive strength of over 2.0 MPa, and total porosity of 84%. The cell culture experiments demonstrated that the scaffold had the excellent ability to promote the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs). The in vivo results showed that the intramedullary nail fixation maintained the initial stability and structural integrity of the implants at early stage, promoting the osteogenic process both guided and induced by the BCP scaffolds. At 9 months postoperatively, good integration between the implants and host bone was observed, and a large amount of newborn bones formed, accompanying with the degradation of the material. At 18 months postoperatively, almost the complete new bone substitution in the defect area was achieved. The maximum bending strength of the repaired bone defects reached to the 100% of normal femur at 18 months post-surgery. Our results demonstrated the good potential of osteoinductive BCP bioceramics in the regenerative repair of large load-bearing bone defects. The current study could provide an effective method to treat the clinical large segmental bone defects.

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Section: Introductionmentioning

confidence: 99%

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Zhi

Xiao-hua

Sun

et al. 2022

Bioactive Materials

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“…The bands usually appeared in the range of 3440–3412 cm −1 are representative of water molecule, 44 these peaks were identified in all of our samples. The carbonate (CO 3 2− ) faint bands were found between 1400 and 1500 cm −1 27,31,45 . These bands were more observable at higher calcination time, that is 5 h (Figure 4B).…”

Section: Resultsmentioning

confidence: 92%

Low‐cost synthesis of nano‐hydroxyapatite from carp bone waste: Effect of calcination time and temperature

Bahraminasab

Doostmohammadi

Alizadeh

2021

Int J Applied Ceramic Tech

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is a common and popular biomaterial for bone regeneration. About 70% of bone structure and essentially all of the enamel in teeth are composed of HA. It has been used in orthopedic and dental applications such as dental implants, bone grafts, orthopedic implants, and bone scaffolds. [1][2][3][4][5] The reason is the excellent bioactivity, adequate mechanical characteristics, osteoconductive, and angiogenic properties, without toxicity, inflammatory, or antigenic reactions. 6 Nano-hydroxyapatite (nano-HA), particularly, is considered as one of the most biocompatible and bioactive materials that has been used and accepted in orthopedics and dentistry. [7][8][9] For example, it has been extensively used in periodontics and in oral and maxillofacial surgical procedures. The inorganic part of bone extra cellular matrix (ECM) contains nano-sized crystallites of calcium phosphate similar to HA. 10 Nano-HA has an outstanding osteoinductive capacity and improves bone-to-implant integration. 11 This nanomaterial also has been employed in the products used for oral care to treat the dentin hypersensitivity (DH) and promote enamel demineralization. It has been shown that nano-HA is capable of reducing the pain associated with DH because the nanoparticles are very small and can readily enter and fill the tubules in dentin. These nanoparticles precipitate inside the dentin tubules and block the nerves interaction with the external stimuli. They can also set down onto the surface of enamel and demineralize the early enamel caries, leading to a new apatite layer formation, which subsequently increases the enamel surface hardness and therefore prevents the tooth decay. These benefits are due to high similarity of morphology and crystal structure of nano-HA with tooth enamel. 12,13 HA can be simply synthesized or extracted from the natural sources, including eggshell, seashell, bovine, or fish bones. [14][15][16][17][18] Fish bone as an alternative natural source for HA production recently has received a lot of attention because of low cost and easy manufacturing regarding the many

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“…corresponded to the tensile vibration of C-H bond on methylene of BF existed in n-HA/BF composite membrane. In addition, the characteristics peaks at 3567.2 cm -1 attributed to the tensile vibration of OHand the peaks at 1095 cm -1 , 604 cm -1 and 565 cm -1 of PO 4 3 -were related to n-HA (Chesley,et al, 2020). The peak position did not transfer obviously when n-HA was added into BF, which indicated that n-HA was simply blended with BF without chemical change.…”

Section: Resultsmentioning

confidence: 96%

Effect of Different Preparation Conditions On The Properties of Bamboo Fiber-Based Bioactive Composite Membrane

Liuyun

Jiang

et al. 2022

Preprint

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A novel nano-hydroxyapatite/bamboo fiber (n-HA/BF) bioactive composite membrane was obtained by a simple casting technique. The membrane forming mechanism and the effects of different forming membrane methods, drying methods and n-HA amounts on the properties of n-HA/BF membrane were investigated by Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle, electromechanical universal tester, in vitro soaking in simulated body fluid (SBF) and in vitro cell cultureexperiment. The results demonstrated that the n-HA dispersity in BF matix was not affected by the prepartion condition, however, the morphologies of membrane was determined by the different preparation conditions owing to different hydrogen bond shrinkage. Moreover, the hydrophilicity of the composite membrane was improved under the condition of the membrane formation in oven, freeze drying and high addition content of n-HA, and the mechanical properties of composite membrane depended on n-HA content. In vitro soaking behavior indicated that the degradability and bone-like apatite deposition could be controled by differentpreparation conditions. And the cell proliferation experiment showed that the n-HA/BF composite membranes obtained under different preparation conditions were all non-toxic. The above results indicated that the n-HA/BF composite membrane could be obtained by a simple casting technique, and the properties could be controlled by adopting different preparation conditions, which would have a great promising as guide bone tissue regeneration (GBR) membrane, and the study would provide a new application for BF in biomedical field.

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One-step hydrothermal synthesis with in situ milling of biologically relevant hydroxyapatite

Cited by 33 publications

References 23 publications

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants

Low‐cost synthesis of nano‐hydroxyapatite from carp bone waste: Effect of calcination time and temperature

Effect of Different Preparation Conditions On The Properties of Bamboo Fiber-Based Bioactive Composite Membrane

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