One-step preparation of the engineered titanium implant by rationally designed linear fusion peptides with spacer-dependent antimicrobial, anti-inflammatory and osteogenic activities

Xin, Haoqian; Chen, Junjian; Li, Tianjie; Hu, Guoqing; Fang, Zhou; Zhou, Haiyan; Guo, Kunzhong; Wang, Lin; Wang, Yingjun

doi:10.1016/j.cej.2021.130380

Cited by 15 publications

(8 citation statements)

References 81 publications

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“…A one-step reaction between the chemical groups was used to fix BFP-1 on the acid-etched Ti implants. In vivo experiments indicated that Ti implants loaded with FPs (PEG spacer no more than 12) inhibited the activity of most clinical bacteria and promoted osseointegration in rabbit models ( Figure 2 E) [ 76 ].…”

Section: Local Drug Delivery Systems With Ti-based Implantsmentioning

confidence: 99%

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Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

et al. 2022

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Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.

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Section: Local Drug Delivery Systems With Ti-based Implantsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

et al. 2022

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“…In the treatment of bone defects, in addition to considering the promoting effect of implants on bone regeneration, a series of biological reactions that may be triggered by implants, such as bacterial infection and immune response, are also clinical problems that cannot be ignored. − Caused by the adhesion and proliferation of bacteria on the implant surface, infection is a common clinical disease, which often recurs repeatedly over a long period of time after surgery. The existence and spread of infection may affect the treatment of bone defects, lead to the expansion of wound area, and even endanger the health of patients. , In addition, bacterial infection and implantation of biomaterials may cause or aggravate an immune response . Immune response is also known as a foreign body reaction; a severe or acute immune response can lead to encapsulation of the implant and damage the osteogenic process.…”

Section: Introductionmentioning

confidence: 99%

“…The existence and spread of infection may affect the treatment of bone defects, lead to the expansion of wound area, and even endanger the health of patients. 14,15 In addition, bacterial infection and implantation of biomaterials may cause or aggravate an immune response. 16 T h i s c o n t e n t i s Immune response is also known as a foreign body reaction; a severe or acute immune response can lead to encapsulation of the implant and damage the osteogenic process.…”

Section: ■ Introductionmentioning

confidence: 99%

Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities

Chen

Zhu

et al. 2022

ACS Appl. Mater. Interfaces

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Current artificial periostea mainly focus on osteogenic activity but overlook structural and mechanical anisotropy, as well as the importance of antibacterial and anti-inflammatory properties. Here, inspired by the anisotropic structure of wood, the delignified wood (named white wood, WW) with a porous and highly oriented cellulose fiber skeleton was obtained, which was further filled with polyvinyl alcohol (PVA) hydrogel loaded with curcumin (Cur) and phytic acid (PA). The prepared wood-derived hydrogel composite membranes can not only exhibit an obvious anisotropic structure and good mechanical properties but also sustainably release loaded drugs to obtain long-term biological activities. Creatively, PA can effectively improve the bioavailability of Cur; more importantly, Cur and PA play an obvious synergistic effect in antibacterial, anti-inflammatory, and osteogenic activities. Compared with the woodderived hydrogel composite membranes without drug loading, as well as loaded with Cur or PA only, these loaded with Cur and PA are significantly more conducive to inhibiting the growth of bacteria and inflammatory response and facilitating the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. This kind of anisotropic woodderived hydrogel composite membrane with fantastic antibacterial, anti-inflammatory, and osteogenic activities is expected to be ideal artificial periostea.

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“…[25][26][27] However, HDPs are easily degraded by proteases, which greatly limit their application. [25] Therefore, HDP mimicking antimicrobial peptides and polymers have attracted widespread interest in the antimicrobial study, [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] with which peptide polymers can be synthesized from one-pot polymerization and have demonstrated potent antimicrobial activities. [45][46][47][48][49][50] Among the studies of osteomyelitis treatment, very limited reports used antibacterial peptides [51,52] or polymers [53] to compose PMMA bone cement for treatment of MRSA-infected chronic osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

Peptide Polymer‐Doped Cement Acting as an Effective Treatment of MRSA‐Infected Chronic Osteomyelitis

Ying

Cong

et al. 2021

Adv Funct Materials

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Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical prostheses or infected fractures. Currently, antibioticloaded cements are extensively used as the treatment in clinical practice. However, the quick emergence of antibiotic-resistant bacteria has resulted in a formidable challenge in treating chronic osteomyelitis, such as the chronic osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Aiming to address MRSA-infected chronic osteomyelitis, an antibacterial peptide polymer doped polymethylmethacrylate bone cement pellets (PMMA@polymer) is prepared. The peptide polymer is designed as the synthetic mimic of host defense peptide and enables PMMA@polymer to have notable advantages, including complete release of antibacterial agent from PMMA, potent and robust activity against MRSA even after autoclave and enzymatic treatment, and low susceptibility to antibacterial resistance. PMMA@polymer showed potent in vitro activities against MRSA, superior in vivo therapeutic efficacy in a rabbit chronic osteomyelitis model, and low toxicity during the treatment. These advantages and the easy preparation of PMMA@polymer altogether suggest the great potential of PMMA@polymer as an effective treatment of MRSA-infected chronic osteomyelitis. This study opens new avenues in developing antibacterial biomaterials for the treatment of chronic orthopedic infections, frequently caused by drug-resistant bacteria.

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One-step preparation of the engineered titanium implant by rationally designed linear fusion peptides with spacer-dependent antimicrobial, anti-inflammatory and osteogenic activities

Cited by 15 publications

References 81 publications

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities

Peptide Polymer‐Doped Cement Acting as an Effective Treatment of MRSA‐Infected Chronic Osteomyelitis

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