One-Step Synthesis of Amphiphilic Diblock Copolymers from Bacterial Poly([<i>R</i>]-3-hydroxybutyric acid)

Ravenelle, François; Marchessault, R. H.

doi:10.1021/bm025553b

Cited by 77 publications

(87 citation statements)

References 23 publications

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“…This single-step synthesis of mPEGylated PHB proceeded with a concomitant depolymerization of PHB molecular weight to a few thousands. 62 Once formed from oil-in-water emulsion, PHB-PEG diblock copolymer can self-assemble into nanoparticles, which can be potentially employed as drug carriers or binders. Using the same approach, nanometer-sized core-shell micelles were prepared from amorphous amphiphilic block copolymer P(3HV-co-4HB)-mPEG and were further explored in cancer therapy.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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“…Besides, the synthesis of diblock copolymers was achieved in one-step transesterification of PHB with monomethoxy PEG in presence of bis(2-ethylhexanoate) tin as catalyst. [11] However, control in block length is tricky, as only low molar masses copolymers were obtained.…”

Section: Introductionmentioning

confidence: 99%

Controlled Synthesis of Well Defined Poly(3‐hydroxyalkanoate)s‐based Amphiphilic Diblock Copolymers Using Click Chemistry

Babinot¹,

Renard²,

Langlois³

2010

Macro Chemistry & Physics

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A modular synthesis of short chain length and medium chain length poly(3‐hydroxyalkanoate)s‐b‐poly(ethylene glycol) (PHAs‐b‐PEG) diblock copolymers is described. First, length‐controlled oligomers of hydrophobic poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBHV), poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx), and poly(3‐hydroxyoctanoate‐co‐hydroxyhexanoate) (PHOHHx) containing a carboxylic acid end group were obtained by thermal treatment, with molar masses ranging from 3 800 to 15 000 g · mol−1. After quantitative functionalization with propargylamine, ligation with azide‐terminated poly(ethylene glycol) of 5 000 g · mol−1 was accomplished using the copper (I) catalyzed azide alkyne cycloaddition (CuAAC). Well‐defined diblock copolymers were obtained up to 93% yield, with molar masses ranging from 9 900 to 23 100 g · mol−1. All products were fully characterized using 1H NMR, COSY, SEC, TGA, and DSC. magnified image

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“…17) Over the past 10 years, CLA and CLA matrices have been extensively characterized in a number of studies. [18][19][20][21] However, the compaction properties of CLA have never been studied in detail. CLA is a chemically modified starch that may exhibit a consolidation behavior different from that of pregelatinized starch.…”

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confidence: 99%