One-step synthesis of monodisperse, water-soluble ultra-small Fe3O4 nanoparticles for potential bio-application

Abstract

We report that ultra-small, monodisperse, water-dispersible magnetite (Fe(3)O(4)) nanoparticles can be synthesized by a facile one-pot approach using trisodium citrate as crystal grain growth inhibitor and stabilizer in polyol solution. The resultant Fe(3)O(4) nanoparticles exhibit an excellent long-term colloidal stability in various buffer solutions without any modification. They are also superparamagnetic at room temperature and their magnetic property relies heavily on their size. Due to the low magnetization and good water-dispersibility, the 1.9 nm-sized Fe(3)O(4) nanoparticles reveal a low r(2)/r(1) ratio of 2.03 (r(1) = 1.415 mM(-1) s(-1), r(2) = 2.87 mM(-1) s(-1)), demonstrating that they can be efficient T(1) contrast agents. On the other hand, because of the excellent magnetic responsivity, the 13.8 nm-sized Fe(3)O(4) nanoparticles can be readily modified with nitrilotriacetic acid and used to separate the protein simply with the assistance of a magnet. In addition, these Fe(3)O(4) nanoparticles may be useful in other fields, such as hyperthermia treatment of cancer and targeted drug delivery based on their size-dependent magnetic property and excellent stability.

Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

“…The hydrodynamic size of 7.3-nm measured in SIO-3 suggests the thinnest coating layer among those IONPs with core size below 5 nm, which may play the significant role in preserving the T 1 contrast enhancing effect due to less restraints in water exchange between inner and outer layers. 21, 24, 27, 28, 30 Moreover, the small hydrodynamic size indicates the single dispersion of SIO-3 in the aqueous solution, preventing the T 2 effect caused by the aggregation. 23 The oligosaccharide coated particles were stable and highly dispersed in the aqueous solution at room temperature for at least 2 months, showing no aggregation (Figure S3).…”

Removal of tetracycline from aqueous solution by a Fe3O4 incorporated PAN electrospun nanofiber mat

“…082-1533), i.e. 30.1 ○ (220), 35.5 ○ (311), 43.1 ○ (400), 57.6 ○ (511), 62.7 ○ (440) (Shen et al, 2013). Loss of diffraction peaks relating to Fe 3 O 4 from Fe-NFM's XRD pattern is likely due to the limited growth of Fe 3 O 4 NPs on the nanofibers surface.…”

“…Fe-NFM was synthesized by a modified literature method (Shen et al, 2013). Briefly, 4 mmol anhydrous FeCl 3 , 1.6 mmol Na 3 Cit and 12.0 mmol NaAc were consecutively added into 40 mL DEG solution with continuously stirring at 80°C until a homogenous solution was formed.…”

The synthesis and characterization of monodispersed chitosan-coated Fe3O4 nanoparticles via a facile one-step solvothermal process for adsorption of bovine serum albumin

“…Among the various methods for the preparation of Fe 3 O 4 NPs, the solvothermal approach is one of great significance [6-9]. Under the solvothermal conditions, Fe 3 O 4 NPs were usually composed of multiple single-domain magnetic nanocrystals.…”