One‐step synthesis of triarm block copolymers via simultaneous reversible‐addition fragmentation chain transfer and ring‐opening polymerization

Abstract

One‐step synthesis of star copolymers by reversible addition–fragmentation chain transfer (RAFT) and ring‐opening polymerization (ROP) by using a novel dual initiator is reported. Triarm block copolymers comprising one polystyrene (or polyacrylamide) arm and two poly(β‐butyrolactone) arms were synthesized in one‐step by simultaneous RAFT polymerization of styrene (St) (or acrylamide, designated as AAm) and ROP of β‐butyrolactone (BL) in the presence of a novel trifunctional initiator, 1,2‐propanediol ethyl xanthogenate (RAFT‐ROP agent). This dual initiator was obtained through the reaction of 3‐chloro‐1,2‐propanediol with the potassium salt of ethyl xanthogenate. The principal parameters such as monomer concentration, initiator concentration, and polymerization time that affect the one‐step polymerization reaction were evaluated. The characterization of the products was achieved using Fourier‐transform infrared spectroscopy (FTIR), 1H‐nuclear magnetic resonance (1H‐NMR), 13C‐nuclear magnetic resonance (13C‐NMR), Gas chromatography–mass spectrometry (GC–MS), gel‐permeation chromatography (GPC), thermogravimetric analysis (TGA), and fractional precipitation (γ) techniques. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

Synthesis and characterization of poly(vinyl chloride-graft-2-vinylpyridine) graft copolymers using a novel macroinitiator by reversible addition-fragmentation chain transfer polymerization

“…Hence, it may be expected that they have shorter poly(2-vinylpyridine) segments, which is confirmed by a decrease in the molecular weights of the graft copolymers, as shown in Table 1. The same situation was also observed in our previous articles (58)(59)(60). Increasing the amount of monomers also generally causes an increase in both the yield and the molecular weights of the copolymers as expected.…”

“…Polymers of a well-defined structure and molecular weight can be synthesized by controlled radical-polymerization methods, such as nitroxide-mediated polymerization (37,38), atom-transfer radical polymerization (25,(39)(40)(41)(42)(43)(44), and reversible addition-fragmentation chain transfer (RAFT) polymerization (33,(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). RAFT polymerization is one of the most recently developed controlled radical-polymerization methods and is an important technique for the synthesis of copolymers.…”

Design and synthesis study of the thermo‐sensitive copolymer carrier of penicillin G acylase

“…Meanwhile, the research on poly (N‐isopropylacrylamide) (PNIPAM) block copolymer is more systematic and in‐depth . However, due to its poor biocompatibility and low LCST, it has seriously affected its future application prospects. Recent studies have shown that the biocompatibility of poly ( N N ‐diethylacrylamide) (PDEA) is far superior to that of PNIPAM, and its LCST is also higher than that of PNIPAM.…”

“…42 Meanwhile, the research on poly (N-isopropylacrylamide) (PNIPAM) block copolymer is more systematic and in-depth. [43][44][45] However, due to its poor biocompatibility and low LCST, [46][47][48] it has seriously affected its future application prospects.…”

Synthesis and characterization of ring-type and branched polymers including polyethylene glycols by “click” chemistry

“…"Click" chemistry applications have been available until now [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Macromolecules are used in technological applications and theoretical studies [16][17][18][19][20][21]. Polymers based on polyethylene glycol (PEG) are attractive materials for biomedical, industrial, and chemicals applications, as PEG has unparalleled characters such as superior ion absorbability, flexibility, hydrophilicity, and biocompatibility [22][23][24][25][26][27][28][29][30][31].…”