One Surprise after Another

Leeper, Nicholas J.; Wener, Lianne S.; Dhaliwal, Gurpreet; Saint, Sanjay; Wachter, Robert M.

doi:10.1056/nejmcps040755

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…The peak troponin level even in fulminant forms of myocarditis was reported to be less than 50 ng/ml in majority of published reports [4, 9, 11, 12, 14, 16]. We found only one report describing the clinical course of four patients with fulminant myocarditis with troponin levels that peaked to ∼ 190 ng/ml in 3 survivors and ∼ 1200 ng/ml in the non-survivor.…”

Section: Discussionmentioning

confidence: 69%

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Markedly Elevated Cardiac Bio-Markers at Presentation With Normal Ventricular Function: A Novel Clinical Subset of Myocarditis Manifestation

2011

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We present a case of a 19-year-old woman with myocarditis who had significantly elevated cardiac markers at presentation even before any myocardial damage ensued. The patient had complicated clinical course with ventricular arrhythmia and cardiac arrest requiring resuscitation but eventually recovered completely. Though there is limited information available regarding such cases, the significantly elevated initial cardiac markers in the absence of left ventricular decompensation may probably represent a clinical subset of myocarditis and may portend an impending complicated clinical course. Further systematic research is required to define the clinical phenotype and elucidate underlying mechanisms.

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Section: Discussionmentioning

confidence: 69%

“…Cardiac biomarkers are elevated in about one-third of patients with acute myocarditis [4, 5] and are of help in making the clinical diagnosis [6]. Elevation of cardiac Troponin I is more common than creatine kinase MB as seen from available clinical and experimental data [5].…”

Section: Discussionmentioning

confidence: 99%