One-third of term babies after perinatal hypoxia-ischaemia have transient hearing impairment: dynamic change in hearing threshold during the neonatal period

ZD, Jiang; Wang, J; DM, Brosi; XM, Shao; AR, Wilkinson

doi:10.1080/08035250310007952

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…This infection can cause localized placental hypoxia through direct damage to the placental villi [32] . And yet, perinatal hypoxia is one cause of transitory or permanent HL in newborns [33] . Third, SARS-CoV-2 affects newborns after being transmitted vertically through the placenta.…”

Section: Discussionmentioning

confidence: 99%

Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Meng¹,

Zhu²,

Wang³

et al. 2022

American Journal of Otolaryngology

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Section: Discussionmentioning

confidence: 99%

Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Meng¹,

Zhu²,

Wang³

et al. 2022

American Journal of Otolaryngology

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“…Neonatal hypoxic ischemic encephalopathy, a common disease in perinatal neonates, can cause various neurological sequelae, including epilepsy, cerebral palsy, visual impairment, and mental retardation. Sensorineural hearing loss is a severe complication that is associated with perinatal hypoxia and ischemia [ 1 , 2 ]. Jiang et al reported that 16.2% of infants with perinatal hypoxia-ischemia also presented with impaired cochlear hair cell function [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Attenuates CoCl2-Induced Cochlear Hair Cell Damage through Upregulation of Sirtuin1 and NF-κB Deacetylation

Wang

Yin

et al. 2013

PLoS ONE

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The goals of this study were to investigate the effects of hypoxia on cochlear hair cell damage, and to explore the role of sirtuin1 in hypoxia-induced hair cell damage. Cochlear organotypic cultures from postnatal day 4 rats were used in this study. Hypoxia was induced by treating cochlear explants with CoCl2. Cochlear cultures were treated with CoCl2 alone or in combination with the sirtuin1 activator resveratrol and the sirtuin1 inhibitor sirtinol. Hair cell damage was identified by phalloidin staining and imaged using scanning electron microscopy. RT-PCR and Western blot analyses were used to detect the expression of sirtuin1 and acetylated nuclear factor-κB (NF-κB). Low concentrations of CoCl2 (100–200 μM) did not cause an obvious change in the number and morphology of hair cells, whereas higher concentrations of CoCl2 (300–400 μM) induced swelling of hair cells, accompanied by cell loss. Increased sirtuin1 expression was induced by CoCl2 at 100 to 200 μM, but not at 400 μM. NF-κB acetylation was significantly increased in explants treated with 400 μM CoCl2. Pretreatment with resveratrol prevented CoCl2-induced hair cell loss and acetylation of NF-κB. The protective effect of resveratrol was significantly reduced by sirtinol. CoCl2 induces hair cell damage in organotypic cochleae cultures. Resveratrol attenuates CoCl2-induced cochlear hair cell damage possibly via activation of sirtuin1, which deacetylates NF-κB.

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Hearing screening test in neonates born to COVID-19–positive mothers

et al. 2022

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SARS-CoV-2, the responsible virus for the COVID-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from COVID-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss. This is a retrospective study in a regional pediatric hospital. The medical records of newborns ( n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study. For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested. Conclusion : Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies. What is known: • The pathogenetic mechanism of the viral-induced impairment of the organ of Corti includes direct damage to the hair cells and indirect damage due to the induction of the innate inflammatory response. • Early data suggested that the SARS-CoV-2 virus also has neurotropic properties with manifestations from the sensory epithelia. What is new: • Although the intrauterine infection remains controversial, the expression of the ACE-2 receptor on the placenta and the detection of IgM antibodies, as well as the covid-19 genome in fetuses, make the vertical transmission tenable. • In our study, the newborn hearing screening results indicate that COVID-19 infection during pregnancy is not a risk factor for hearing loss.

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One-third of term babies after perinatal hypoxia-ischaemia have transient hearing impairment: dynamic change in hearing threshold during the neonatal period

Abstract: Hearing threshold is elevated in about one-third of term babies after hypoxia-ischaemia. The elevated threshold decreases progressively after birth, and returns to normal by one month in most babies. The threshold correlates weakly with the severity of encephalopathy.

Cited by 5 publications

References 20 publications

Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Resveratrol Attenuates CoCl2-Induced Cochlear Hair Cell Damage through Upregulation of Sirtuin1 and NF-κB Deacetylation

Hearing screening test in neonates born to COVID-19–positive mothers

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