One versus four heat treatments in combination with radiotherapy in metastatic mammary carcinoma

Arcangeli, Giorgio; Casale, C.; Colistro, F.; Benassi, Marcello; Lovisolo, Giorgio A.; Begnozzi, L.

doi:10.1016/0360-3016(91)90334-z

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…In his studies, Arcangeli [3] used higher temperatures of 42.5-43.5°C for 1 h and the overall response rate did not seem greater than what we have achieved at the lower temperatures. Arcangeli [3] showed that patients who received hyperthermia twice a week did better in terms of long-term control than patients who did not receive hyperthermia, and patients who received one treatment per week did not do significantly better than patients who received no hyperthermia.…”

Section: Discussionmentioning

confidence: 99%

“…Arcangeli [3] showed that patients who received hyperthermia twice a week did better in terms of long-term control than patients who did not receive hyperthermia, and patients who received one treatment per week did not do significantly better than patients who received no hyperthermia. Bicher [8] reported that daily hyperthermia five times a week for a total of 25 times pro duced superior results over those which could be obtained with ten hyperthermia treatments twice a week (table 4).…”

Section: Discussionmentioning

confidence: 99%

“…Bicher [8] reported that daily hyperthermia five times a week for a total of 25 times pro duced superior results over those which could be obtained with ten hyperthermia treatments twice a week (table 4). In reviewing the literature [3,8], patients who received 1-8 deep heat treatments did no better than patients who received 9-15 treatments. However, when patients re ceived 25 treatments those patients were felt to have a better response.…”

Section: Discussionmentioning

confidence: 99%

“…The use of hyperthermia alone or in conjunction with radiation therapy or chemo therapy offers an alternative to the 'wait, watch and send the patient home to die' policy. Encouraging results utiliz ing hyperthermia in previously irradiated tissues have been reported by several authors [2][3][4][5][6][7][8] and have opened the way for retreatment of recurrent tumors lying in pre viously heavily irradiated normal tissue.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Experience with Hyperthermia in Conjunction with Radiation Therapy

Shidnia¹,

Hornback²,

Ford³

et al. 1993

Oncology

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The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been averaged and the results were evaluated for complete, partial, or no response. All patients had previously failed conventional radiation therapy, chemotherapy and surgery. Responses were defined as: (1) Complete response – lesions that completely disappeared during treatment and the response was sustained for a minimum of 6 months. (2) Partial response -lesions that underwent a reduction in size of greater than 50%. (3) No response – less than 50% reduction in tumor size during the course of treatment. Response varied somewhat according to histology and anatomical site of treatment; however, complete response was achieved in 45 %, partial response in 48% (for an overall response of 93%), and no response in 7% of the patients. The response achieved varied with temperature attained and a minimum temperature of 40 °C for 40min produced the greatest number of responses. Response to hyperthermia was directly related to the temperature achieved and the length of time the temperature was applied.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Experience with Hyperthermia in Conjunction with Radiation Therapy

Shidnia¹,

Hornback²,

Ford³

et al. 1993

Oncology

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“…Hyperthermia involves two biological interactions with radiation, a radiosensitizing effect [9,10] and a direct cytotoxic effect on tumor cells [11] . When the target lesion is heated up to around 42 , the cancer-killing effect of radiation or anticancer drug is enhanced [12] .…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%