Thermo-chemo-radiotherapy for advanced bile duct carcinoma

Kamisawa, Terumi; Kiura, Katsuyuki; Okamoto, Akira

doi:10.1016/s0016-5085(03)82867-6

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…16-18 As to CCA, a case series of 8 patients on regional hyperthermia with 8 MHz frequency in combination with chemoradiation therapy was reported to be a promising treatment, increasing both local control and long-term survival. 19 The higher the frequency, the greater the attenuation and the lower is the penetration. 20 The REMISSION 1°C device has a frequency of 0.46 MHz, the lowest frequency ever reported.…”

Section: Discussionmentioning

confidence: 99%

Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

et al. 2017

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Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

et al. 2017

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“…Finally, the result showed that the overall survival of the group treated with TCRT compared to conventional systemic chemotherapy was greater, whereas no difference was found between group GEM-based systemic chemotherapy and TCRT (Egawa et al, 2008). Additionally, results from another study have demonstrated that TCRT can enhance survival times and induce a meaningful response in patients with advanced gallbladder cancer (Kamisawa, Tu, Ishiwata, et al, 2005). , estrogen receptornegative; GBM, glioblastoma =; HER2 À , human epidermal growth factor receptor 2 negative; HPV, human papilloma virus; KRAS, kirsten rat sarcoma virus;…”

Section: Gallbladder Carcinomamentioning

confidence: 99%

The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer

Shirvalilou,

Tavangari,

Parsaei

et al. 2023

WIREs Nanomed Nanobiotechnol

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A pivotal cause of death in the modern world, cancer is an insidious pathology that should be diagnosed at an early stage for successful treatment. Development of therapeutic interventions with minimal invasiveness and high efficacy that can discriminate between tumor and normal cells is of particular interest to the clinical science, as they can enhance patient survival. Nanoparticles are an invaluable asset that can be adopted for development of such diagnostic and therapeutic modalities, since they come in very small sizes with modifiable surface, are highly safe and stable, and can be synthesized in a controlled fashion. To date, different nanoparticles have been incorporated into numerous modalities such as tumor‐targeted therapy, thermal therapy, chemotherapy, and radiotherapy. This review article seeks to deliver a brief account of recent advances in research and application of nanoparticles in hyperthermia‐based cancer therapies. The most recent investigations are summarized to highlight the latest advances in the development of combined thermo‐chemo‐radiotherapy, along with the challenges associated with the application of nanoparticles in cancer therapy.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Thermo-chemo-radiotherapy for advanced bile duct carcinoma

Cited by 2 publications

References 3 publications

Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer

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