One-Way Intestinal Perfusion of PVP/VA–Poloxamer 188–Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC–T6 Cell Proliferation

Gao, Jie; Shi, Yaoping; Han, Yunfeng; Tang, Xi; Bi, Ruohong; Pan, Lin; Lai, Xiulan

doi:10.1208/s12249-022-02228-6

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Блок-сополимеры ЭО и ПО все чаще находят применение как компоненты систем доставок химиотерапевтических агентов [15]. В 2022 г. был опубликован целый ряд исследований, описывающих создание и исследование различных систем доставки куркумина -натурального противоопухолевого средства -с полоксамерами для корректировки низкой биодоступности и растворимости активного ингредиента [16][17][18]. Полученные системы доставки -полимерные наночастицы [16], наногель [17], твердые дисперсии [18], созданные на основе полоксамера 188, полоксамера 403 и полоксамера 407, обеспечивали высокую стабильность противоопухолевой композиции, эффективную доставку активных агентов в опухолевые клетки и улучшенную выживаемость после химиотерапии, определенную в доклинических исследованиях in vivo [16].…”

Section: Introductionunclassified

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Bakhrushina,

Pyzhov,

Sakharova

et al. 2023

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Block copolymers of ethylene oxide and propylene oxide (EO/PO block copolymers) are polymeric non-ionic surfactants with a high hydrophilic–lipophilic balance also referred to as pluronics, poloxamers, or proxanols. These compounds are among the most demanded modern excipients for the production of medicines. EO/PO block copolymers are used both in the production of traditional (liquid, semi-solid, and solid) dosage forms and as part of targeted delivery systems. The extensive application of EO/PO block copolymers is due to the diverse array of their properties, including not only solubilising, emulsifying, gelling, and other effects but also thermoreversibility, which is essential for developing in situ delivery systems and 3D printing technologies.The aim of the study was to evaluate the potential of EO/PO block copolymers for medicinal use and to assess the range of medicinal products approved in the Russian Federation that contain EO/PO block copolymers.This review presents an analysis of the register of poloxamer-containing medicines approved in the Russian Federation, a list of the largest manufacturers of EO/PO block copolymers in the world, and a study of the possibility to use copolymers for medical purposes. Currently, there are more than 10 chemical manufacturers producing EO/PO block copolymers for the pharmaceutical, biotechnology, and other industries around the world. EO/PO block copolymers are included in more than 60 medicinal products present in the Russian pharmaceutical market; this observation indicates the need to phase out the import of poloxamers.

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Section: Introductionunclassified

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Bakhrushina,

Pyzhov,

Sakharova

et al. 2023

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

Budiman,

Hafidz,

Azzahra

et al. 2024

Polymers

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Plant extracts demonstrate significant potential as a rich source of active pharmaceutical ingredients, exhibiting diverse biological activities and minimal toxicity. However, the low aqueous solubility of extracts and their gastrointestinal permeability, as well as their poor oral bioavailability, limit clinical advancements due to drug delivery problems. An amorphous solid dispersion (ASD) delivers drugs by changing an active pharmaceutical ingredient (API) into an amorphous state to increase the solubility and availability of the API to the body. This research aimed to analyze and summarize the successful advancements of ASD systems derived from plant extracts, emphasizing characterization and the effects on dissolution and pharmacological activity. The results show that ASD systems improve phytoconstituent dissolution, bioavailability, and stability, in addition to reducing dose and toxicity. This research demonstrates the significance of ASD in therapeutic formulations to augment the pharmacological activities and efficacy of medicinal plant extracts. The prospects indicate promising potential for therapeutic applications utilizing ASD systems, alongside medicinal plant extracts for clinical therapy.

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One-Way Intestinal Perfusion of PVP/VA–Poloxamer 188–Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC–T6 Cell Proliferation

Cited by 2 publications

References 11 publications

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

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