One-year biodegradation study of UHMWPE as artificial joint materials: Variation of chemical structure and effect on friction and wear behavior

Ge, Shirong; Kang, Xueqin; Zhao, Yujie

doi:10.1016/j.wear.2010.11.048

Cited by 35 publications

(21 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies have supposed that mechanical properties of UHMWPE are homogeneous throughout the component and unchanged with time of implantation [6,7,8,9]. Anyway, it must be taken into account that UHMWPE undergoes deterioration in a physiological environment due to chemical reactions that accelerate the wear mechanisms [10].…”

Section: Introductionmentioning

confidence: 99%

Tribological Behavior of Nanocomposites Based on UHMWPE Aged in Simulated Synovial Fluid

et al. 2018

View full text Add to dashboard Cite

Ultra High molecular weight polyethylene (UHMWPE) suffers wear degradation in total joint replacements and it needs to be improved. Thus, we enhanced wear resistance of UHMWPE with carbon nanofiller and paraffin oil and studied its tribological behavior in Simulated Synovial Fluid (SSF) for 60 days at 37 °C to reproduce the conditions of a real joint. Ageing in biological fluid accelerates the wear action but nanocomposite exhibited a higher wear resistance compared to UHMWPE because of its higher structural homogeneity. Carbon nanofiller closes the porosity of UHMWPE hindering SSF to penetrate inside. Wear resistance of the nanocomposite with 1.0 wt.% of CNF improved of 65% (before ageing) and of 70% (after 60 days in SSF) with respect to pure UHMWPE.

show abstract

Section: Introductionmentioning

confidence: 99%

Tribological Behavior of Nanocomposites Based on UHMWPE Aged in Simulated Synovial Fluid

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It indicated that oxidation occurred accompanying the in vitro ALN release. In fact, the oxidation of UHMWPE occurred frequently in other studies and was believed to involve a complex mechanism, which depended on several factors, such as sterilization conditions, storage time before implant and implantation time 30, 31. In addition, the characteristic peaks of ALN (i.e., PO stretching vibration at 1095 cm −1 , CN absorption at 1133 cm −1 , and CO stretching at 1265 cm −1 ) were observed in the FTIR spectra of UHMWPE‐ALN wear particles before and after immersion in PBS for 100 d 16.…”

Section: Resultsmentioning

confidence: 99%

Study on in vitro release and cell response to alendronate sodium‐loaded ultrahigh molecular weight polyethylene loaded with alendronate sodium wear particles to treat the particles‐induced osteolysis

Bai

Liu

et al. 2012

J Biomedical Materials Res

View full text Add to dashboard Cite

The aim of this study is to investigate in vitro release and cell response to wear particles of ultrahigh molecular weight polyethylene loaded with alendronate sodium (UHMWPE-ALN), a potent bone resorption inhibitor. Wear particles of UHMWPE-ALN with different ALN contents (0.5 wt % or 1.0 wt %) and size ranges (<45 μm or 45-75 μm) were cocultured with macrophages (RAW264.7) and osteoblasts (MC3T3-E1), respectively. The in vitro ALN release was divided into three stages: an initial burst release, subsequent rapid release, and final slow release. The particle size and ALN content of UHMWPE-ALN wear particles affected the in vitro release mainly during initial burst and rapid release. Compared with the control cells, UHMWPE-ALN wear particles stimulated a significant elevation of tumor necrosis factor-alpha (TNF-α) release from macrophages but had no obvious effect on interleukin-6 release. However, this stimulation of TNF-α release could be reduced by ALN released from UHMWPE-ALN wear particles. The wear particle size had stronger effect of on the macrophages compared with the ALN concentration. After coculture with UHMWPE-ALN wear particles, osteoblast proliferation and alkaline phosphatase activities increased moderately with the increase in particle sizes and ALN concentrations. These results suggest that incorporation of ALN in UHMWPE-ALN may be an effective approach to prevent or reduce particles-induced osteolysis.

show abstract

“…where ρ eth is equal to 0.790 g/cm 3 . The resulting density value of each sample was the average of n = 3 measurements.…”

Section: Materials Characterizationmentioning

confidence: 99%

“…Debris gives rise to adverse reactions, which lead to osteolysis and aseptic loosening of the prosthesis causing the failure of the entire joint, and hence the revision surgery [2]. After implantation in the human body, indeed, UHMWPE undergoes degrading mechanisms in the physiological environment and for the sliding friction against the other metallic or ceramic harder components of the artificial mobile prostheses [3][4][5]. For this reason, the research of the last years is highly focused on the improvement of mechanical resistance of this material during its use in vitro [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Wear Resistant Nanocomposites Based on Biomedical Grade UHMWPE Paraffin Oil and Carbon Nano-Filler: Preliminary Biocompatibility and Antibacterial Activity Investigation

Catauro

Scolaro

Poggetto³

et al. 2020

Polymers

View full text Add to dashboard Cite

In the present paper, we investigate the effectiveness of nanocomposites (composed of ultra-high molecular weight polyethylene (UHMWPE) mixed with carbon nano-filler (CNF) and medical grade paraffin oil (PO), from the biological point of view. Wear measurements were carried out without (air) and with lubricant (distilled water, natural, and artificial lubricant), and antibacterial activity and cytotoxicity were evaluated. The results highlighted that the presence of CNF is important in the nanocomposite formulation because it reduces the wear rate and prevents oxidative degradation during its processing. An amount of 1.0 wt % of CNF is best because it reaches the optimal distribution within the polymeric matrix, resulting in the best wear resistant, bio-active, and anti-bacterial nanocomposite among all investigated samples.

show abstract

One-year biodegradation study of UHMWPE as artificial joint materials: Variation of chemical structure and effect on friction and wear behavior

Cited by 35 publications

References 56 publications

Tribological Behavior of Nanocomposites Based on UHMWPE Aged in Simulated Synovial Fluid

Tribological Behavior of Nanocomposites Based on UHMWPE Aged in Simulated Synovial Fluid

Study on in vitro release and cell response to alendronate sodium‐loaded ultrahigh molecular weight polyethylene loaded with alendronate sodium wear particles to treat the particles‐induced osteolysis

Wear Resistant Nanocomposites Based on Biomedical Grade UHMWPE Paraffin Oil and Carbon Nano-Filler: Preliminary Biocompatibility and Antibacterial Activity Investigation

Contact Info

Product

Resources

About