The ongoing coronavirus disease 2019 (COVID-19) pandemic has had a huge impact on our personal and professional life alike. In this special issue of the Netherlands Heart Journal focussing on COVID-19, several aspects of the pandemic influencing our profession are highlighted.Starting with a broader overview, de Vries [1] very thoroughly describes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle, its transmission and the clinical and immunological features of COVID-19. Different approaches to developing a COVID-19 vaccine are touched upon and the perspectives for treating COVID-19 with antiviral drugs, immunomodulatory agents and anticoagulants/antithrombotics are described. Several of the aforementioned categories of medication may influence the cardiovascular system directly, hence influencing the care and treatment of our cardiac patients. van den Broek et al.[2] describe the consequences of using chloroquine, a potential therapeutic option in COVID-19. They show a significant and clinically relevant prolongation of the QTc interval in chloroquinetreated patients, highlighting the need for intensive ECG monitoring in COVID-19 patients. The article of Sinkeler et al. [3] draws the same conclusion from an even larger cohort of COVID-19 patients, whilst adding that since the computer-based algorithm for calculating the QTc interval seems to overestimate the actual QTc, manual QTc measurements are advisable before adjusting chloroquine doses or even withdrawing chloroquine treatment. Reviewing this, Wilde and Offerhaus [4] comment on the use of hydroxychloroquine and chloroquine and refer to them