Onion extract (<i>Allium cepa</i>L.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress

Jaiswal, Nidhi; Rizvi, Syed Ibrahim

doi:10.1002/jsfa.6620

Cited by 39 publications

(23 citation statements)

References 50 publications

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“…Quercetin and, to a lesser extent, catechin induced similar effects [28]. In this animal model, the administration of Aronia melanocarpa juice statistically restored the PON activity of rats on a high-fructose and unsaturated fat diet [29].…”

Section: Plant Preparationsmentioning

confidence: 99%

“…In male Wistar rats receiving a 400 mg/kg dose of rutin for two weeks, the hepatic activity of PON1 increased by 17% compared to controls [60]. In this animal model, Jaiswal et al showed that administration of quercetin, and to a lesser extent catechin, significantly attenuated the adverse effects of HgCl 2 by upregulating PON1 activity and protected against LDL oxidation and lipid peroxidation [28]. A similar result was found by Mohammadshahi et al, who also observed a recovery in the decreased PON1 activity in arthritic rats when administering soy isoflavones (genistein and daidzein) for 50 days [33].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Lou-Bonafonte

Gabás‐Rivera

Navarro

et al. 2017

IJMS

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Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments.

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Section: Plant Preparationsmentioning

confidence: 99%

Section: Phenolic Compoundsmentioning

confidence: 99%

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Lou-Bonafonte

Gabás‐Rivera

Navarro

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Different experimental models involving toxins or metabolic diseases ( i.e. , HgCl 2 toxicity [ 108 ], ethylene glycol-induced renal failure [ 109 ], streptozotocin-induced diabetic rats [ 110 ], Apoe -deficient mice [ 111 , 112 ] and cystathionine beta synthase-deficient mice [ 113 ]); catechins, alone or in combination with other polyphenols (quercetin) or foods (wine); or procyanidins (a group of flavonoids that are oligomeric forms of catechins present in red wine, grapes and apples) [ 110 ] have demonstrated up-regulation of PON1 levels or protective activity against LDL oxidation and lipid peroxidation. These studies raised important caveats such as the influence of the chemical nature of flavonoids or isoflavonoids, the experimental approach and selection of the animal model.…”

Section: Pon1 and Chemical Compounds Present In Mediterranean Dietmentioning

confidence: 99%

PON1 and Mediterranean Diet

et al. 2015

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The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1) has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

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“…Medicinal plants such as Morus alba leaves extract [82], ginger [84], nuts [85], pumpkin [86], B-glucan [87], berry fruits [88], yellow onion (Allium cepa L.) [89] and resveratrol [90] have the capability to improve hypercholesterolemia by reducing total lipids, cholesterol and triglycerides. Many of the plants contain bioactive components having a potent antioxidant activity.…”

Section: Impact Of Phytotherapymentioning

confidence: 99%

Hypercholesterolemia-induced ocular disorder: Ameliorating role of phytotherapy

2015

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Onion extract (Allium cepaL.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress

Abstract: The findings may explain the anti-atherosclerotic effect of onion and also foods containing quercetin and catechins.

Cited by 39 publications

References 50 publications

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

PON1 and Mediterranean Diet

Hypercholesterolemia-induced ocular disorder: Ameliorating role of phytotherapy

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