Path planning and tracking are essential technologies for unmanned surface vessels (USVs). The kinodynamic constraints and actuator faults, however, bring difficulties in finding feasible paths and control efforts. This paper proposes a collision avoidance strategy for USV by developing the kinodynamic rapidly exploring random tree-smart (kinodynamic RRT*-smart) algorithm and the fault-tolerant control method. By utilizing the triangular inequality and the intelligent biased sampling strategy, the kinodynamic RRT*-smart shows its advantages in terms of path length, cost and running time. With consideration of kinodynamic constraints, a feasible and collision-free trajectory can be provided. Then, a radial basis function neural network-based model predictive control (RBF-MPC) method was designed that compensates for the model’s uncertainties by developing the radial basis function neural network (RBF-NN) approximator and by constructing a feedback-state training dataset in real time. Furthermore, two types of fault situation were analyzed considering the thruster failure. We established the faults’ mathematical models and investigated the fault-tolerant strategies for different fault types. The simulation studies were conducted to validate the effectiveness of the proposed strategy. The results show that the proposed planning and control methods can avoid obstacles in faulty conditions.