2019
DOI: 10.1007/s11302-019-09648-3
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Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier’

Abstract: A major component of slowly reversible hearing loss which develops with sustained exposure to noise has been attributed to release of ATP in the cochlea activating P2X 2 receptor (P2X 2 R) type ATP-gated ion channels. This purinergic humoral adaptation is thought to enable the highly sensitive hearing organ to maintain function with loud sound, protecting the ear from acoustic overstimulation. In the study that established this hearing adaptation mechanism as reported by Housley et al. (Proc Natl Acad Sci U S … Show more

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Cited by 10 publications
(9 citation statements)
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“…This paracrine humeral purinergic signaling is thought to complement the medial olivocochlear reflex suppression of the cochlear amplifier that is mediated by the type 2 spiral afferents that innervate the outer hair cells (Froud et al, 2015). Our observation of P2X 2 only in the hair cells and support cells is consistent with recent research that directly implicated the outer hair cell rather than the spiral afferents in the P2X 2 -mediated pathways (Cederholm et al, 2019).…”
Section: Discussionsupporting
confidence: 90%
See 2 more Smart Citations
“…This paracrine humeral purinergic signaling is thought to complement the medial olivocochlear reflex suppression of the cochlear amplifier that is mediated by the type 2 spiral afferents that innervate the outer hair cells (Froud et al, 2015). Our observation of P2X 2 only in the hair cells and support cells is consistent with recent research that directly implicated the outer hair cell rather than the spiral afferents in the P2X 2 -mediated pathways (Cederholm et al, 2019).…”
Section: Discussionsupporting
confidence: 90%
“…Lastly, we investigated the expression of tdTomato in the cochlea, based upon reports that P2X 2 is important for purinergic-mediated adaptation and protection against noise-induced ototoxicity (Yan et al, 2013;Cederholm et al, 2019). We found robust expression of tdTomato in numerous specialized cells within the organ of Corti, including in the inner hair cells, outer hair cells, Deiters cells, Hensen's cells and the outer pillar cells (Fig.…”
Section: Resultsmentioning
confidence: 98%
See 1 more Smart Citation
“…NIHL is primarily caused by damage to the cochlear HCs and associated synaptopathy. Contributions to a temporary threshold shift (TTS) include reversible damage to the HC stereocilia or synapses beneath it, while a moderate TTS reflects protective purinergic hearing adaptation, which is thought to enable the highly sensitive hearing organ to maintain function even in loud sound, protecting the ear from acoustic overstimulation 9 , 10 . Permanent threshold shifts (PTS) represent permanent damage or loss of the HCs and synapses.…”
Section: Introductionmentioning
confidence: 99%
“…the SmartOAE from Intelligent Hearing Systems, USA, or the Hear-ID system from Mimosa Acoustics, USA. The higher frequency capability seems to be an important option and might be useful for detecting early hearing damage caused by noise or ototoxic drugs [14][15][16][17][18][19][20][21][22][23][24][25][26]. In addition, extension of the frequency band in DPOAE measurement might be helpful in diagnosing people with chronic diseases such as diabetes, renal failure, or juvenile chronic arthritis [27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%