Onset of heart failure determines the hepatic cell death pattern

Herzer, Kerstin; Kneiseler, G; Bechmann, Lars P.; Post, Felix; Schlattjan, Martin; Sowa, Jan-Peter; Neumann, Till; Marggraf, G.; Erbel, Raimund; Gerken, Guido; Canbay, Ali; Jochum, Christoph

doi:10.1016/s1665-2681(19)31566-2

Cited by 16 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding might indicate congestive hepatopathy and/or acute cardiogenic liver injury are associated with circulatory failure. In chronic heart failure, cell death is due to apoptosis whereas necrotic cell death is prominent in acute heart failure [40]. AST, together with cholestasis markers including γ-glutamyltranspeptidase, total bilirubin and alkaline phosphatase were correlated with poor outcome in congestive hepatopathy, while ALT and lactate dehydrogenase were important markers in acute cardiogenic liver injury [41].…”

Section: Discussionmentioning

confidence: 99%

Parameters affecting outcome of paediatric cardiomyopathies in the intensive care unit: experience of an Egyptian tertiary centre over 7 years

Sobeih

El-Saiedi

Khalek

et al. 2020

Libyan Journal of Medicine

View full text Add to dashboard Cite

Introduction: Paediatric cardiomyopathies are rare but serious and often life-threatening conditions. In the absence of cardiac transplant and ventricular assist device as treatment options in our region, it is very important to identify patients at higher risk. The aim of this study was to determine the outcome of patients diagnosed with cardiomyopathies and their prognostic indicators. Patients and methods: This study included 92 cases representing all patients diagnosed with cardiomyopathy who were admitted into the pediatric cardiac intensive care unit during the period from January 2012 to September 2018. The patients were classified into two groups according to the outcome: the first group comprised 69 patients who survived, and the second group comprised 23 patients who died. All medical records were reviewed, and data were recorded and analysed. Results: Patients with cardiomyopathies represented 8.6% (92/1071) of all patients with cardiac diseases who were admitted in the study period and in the target age group (0.5-12 years). Dilated cardiomyopathy (DCM) was the most frequent type of cardiomyopathy among the admitted patients (80 patients), while 6 patients were diagnosed with hypertrophic cardiomyopathy (HCM), 4 were diagnosed with restrictive cardiomyopathy (RCM), and only 2 were diagnosed with mixed DCM-RCM. Seventy patients required inotropic support (76.1%). Assisted mechanical ventilation was used on 15 patients (16.3%). Twenty-three patients (25.0%) died during the 7-year study period. ConclusionsConclusions The occurrence of hypotension, abnormally high liver enzymes, the need for mechanical ventilation and the need for multiple inotropic drugs were found to be statistically significant predictors of mortality, while age, sex, fractional shortening, ejection fraction, presence of mitral regurgitation, mural thrombus, electrolyte disturbance and arrhythmias did not predict or affect patients' outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Parameters affecting outcome of paediatric cardiomyopathies in the intensive care unit: experience of an Egyptian tertiary centre over 7 years

Sobeih

El-Saiedi

Khalek

et al. 2020

Libyan Journal of Medicine

View full text Add to dashboard Cite

show abstract

“…Failure of the pumping heart often leads to the damage of other organs, especially the liver, and the combined dysfunction of heart and liver increases morbidity and mortality [ 1 ]. This study aimed to investigate possible mechanisms that underlie liver injury following heart dysfunction using the animal model of ACF-induced congestive heart failure [ 16 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, congestive heart failure prevents the heart's ability to deliver the appropriate amount of oxygen to a rate proportionate to the demands of the metabolizing tissues that may result in damage to organs such as the liver [ 28 , 31 – 34 ]. In a recent study, elevated serum levels of the peripheral cell death markers M65 and M30 gave first indirect evidence of hepatic apoptotic cell death in patients with liver injury following heart failure [ 1 ]. Here, we investigated the histopathological and ultrastructural changes of the liver as well as the expression of apoptotic cell death markers following heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic heart failure, a progressive disease marked by repeated hospitalizations for episodes of acute decompensation, is frequently complicated by liver dysfunction—one of the most important risk factors for poor clinical outcome and death [ 1 , 2 ]. Particularly right heart failure causes liver congestion which over time leads to liver stiffness and finally may result into liver fibrosis [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a small clinical study investigated the predominant hepatic cell death pattern in heart failure by determining serum levels of hepatic cytokeratin-18 epitopes (M65 and M30) which constitute peripheral cell death markers [ 1 ]. These elevated serum markers gave first indirect evidence that apoptotic cell death seems to contribute to liver injury following heart failure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathological alterations in liver injury following congestive heart failure induced by volume overload in rats

et al. 2017

View full text Add to dashboard Cite

Heart failure has emerged as a disease with significant public health implications. Following progression of heart failure, heart and liver dysfunction are frequently combined in hospitalized patients leading to increased morbidity and mortality. Here, we investigated the underlying pathological alterations in liver injury following heart failure. Heart failure was induced using a modified infrarenal aortocaval fistula (ACF) in male Wistar rats. Sham operated and ACF rats were compared for their morphometric and hemodynamic data, for histopathological and ultrastructural changes in the liver as well as differences in the expression of apoptotic factors. ACF-induced heart failure is associated with light microscopic signs of apparent congestion of blood vessels, increased apoptosis and breakdown of hepatocytes and inflammatory cell inifltration were observed. The glycogen content depletion associated with the increased hepatic fibrosis, lipid globule formation was observed in ACF rats. Moreover, cytoplasmic organelles are no longer distinguishable in many ACF hepatocytes with degenerated fragmented rough endoplasmic reticulum, shrunken mitochondria and heavy cytoplasm vacuolization. ACF is associated with the upregulation of the hepatic TUNEL-positive cells and proapoptotic factor Bax protein concomitant with the mitochondrial leakage of cytochrome C into the cell cytoplasm and the transfer of activated caspase 3 from the cytoplasm into the nucleus indicating intrinsic apoptotic events. Taken together, the results demonstrate that ACF-induced congestive heart failure causes liver injury which results in hepatocellular apoptotic cell death mediated by the intrinsic pathway of mitochondrial cytochrome C leakage and subsequent transfer of activated caspase 3 into to the nucleus to initiate overt DNA fragmentation and cell death.

show abstract

Prognostic value of DCTA scoring system in heart failure

Zhao

Yang

et al. 2020

Herz

View full text Add to dashboard Cite

Onset of heart failure determines the hepatic cell death pattern

Cited by 16 publications

References 16 publications

Parameters affecting outcome of paediatric cardiomyopathies in the intensive care unit: experience of an Egyptian tertiary centre over 7 years

Parameters affecting outcome of paediatric cardiomyopathies in the intensive care unit: experience of an Egyptian tertiary centre over 7 years

Pathological alterations in liver injury following congestive heart failure induced by volume overload in rats

Prognostic value of DCTA scoring system in heart failure

Contact Info

Product

Resources

About