“…The aggregation phenomenon is usually caused by molecule interactions and/or chemical reactions. Using this colorimetric principle, a variety of drugs, metal ions and other analytes have been detected [6–8] . However, LSPR biosensors have exposed some shortcomings, such as small resonance peak (valley) shift, insufficient resonance strength, wide linewidth characteristics, small peak‐to‐valley ratio, and so on, [9] which limit its application in high precision detection of the biochemical anlaysis.…”