Ontogeny of an endogenous, nonopioid and hormonally mediated analgesic system

Hamm, Robert J.; Knisely, Janet S.

doi:10.1002/dev.420200507

Cited by 18 publications

(11 citation statements)

References 40 publications

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“…Short warm water swims in our study produced SIA in 20 and 25 day old rats confirming other ontogenetic studies using maternal deprivation (Kehoe & Blass, 1986), electric shock (Hamm & Knisely, 1984) and cold water swimming (Hamm & Knisely, 1987) as stressors. The temperature and duration of swimming has been shown in adult rats to alter markedly the neurochemical basis of the SIA.…”

Section: Discussionsupporting

confidence: 91%

Swim‐stress‐induced antinociception in young rats

Jackson

Kitchen

1989

British J Pharmacology

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1 Opioid and non-opioid mechanisms have been implicated in the phenomenon of stress-induced antinociception in adult rodents. We have studied stress-induced antinociception in developing rats and characterized differences in the neurochemical basis of this effect in pre-and post-weanling animals. 2 Twenty and 25 day old rats were stressed using warm water (20°C) swimming for 3 or 10min periods and antinociception was assessed by the tail immersion test (50°C). 3 A 3 min swim in 20 and 25 day old rats produced marked antinociception which was blocked by naloxone, Mr 1452, 16-methyl cyprenorphine and levallorphan but not Mr 1453 or N-methyl levallorphan. The b-opioid receptor antagonist ICI 174,864 attenuated stress-induced antinociception in 25 day old rats but was without effect in 20 day old animals. 4 A 10 min swim in 25 day old rats produced antinociception which was non-opioid in nature. In contrast, antinociception was not observed in 20 day old rats after a 10 min swim-stress. 5 Pretreatment of animals with dexamethasone blocked 3 min swim-stress antinociception in 20 and 25 day old animals but had no effect on antinociception induced by a 10 min swim. 6 Swim-stress-induced antinociception can be observed in young rats and dissociated into opioid and non-opioid types dependent on the duration of swimming stress. The non-opioid type appears to develop more slowly and cannot be observed in preweanling rats. The opioid type is a predominantly p-receptor phenomenon in preweanling animals but 6-receptor components are observable in postweanling rats.

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Section: Discussionsupporting

confidence: 91%

Swim‐stress‐induced antinociception in young rats

Jackson

Kitchen

1989

British J Pharmacology

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“…The age-related differences in this study were shown to be non-opioid mediated but were NMDA receptor dependent. Other studies suggest, however, that non-opioid mediated SIA which is potentiated following adrenalectomy, is not age-specific (Hamm and Knisely, 1987;Hamm et al, 1986). A study with human volunteers shows an agerelated decline in SIA (Washington et al, 2000).…”

Section: The Effects Of Age and Experience On Siamentioning

confidence: 94%

Stress-induced analgesia

Butler

Finn

2009

Progress in Neurobiology

561

420

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Abbreviations: SIA, stress-induced analgesia; FCA, fear-conditioned analgesia; GABA, Ȗ-aminobutyric acid; HA, high analgesia; LA, low analgesia; fMRI, functional magnetic resonance imaging; DNIC, diffuse noxious inhibitory control; PAG, periaqueductal grey; RVM, rostroventral medulla; 5-HT, 5-hydroxytryptamine; CB 1 , cannabinoid type 1; CB 2 , cannabinoid type 2; NMDA, N-methyl-D-aspartic acid; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; mGluR, metabotropic glutamate receptor; NK1, neurokinin 1; SP, substance P; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; MGL, monoacylglycerol lipase; HPA, hypothalamo-pituitary-adrenal; ACTH, adrenocorticotropic hormone 3 ABSTRACT For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stressinduced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia sensitivity can vary a great deal depending on age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway.Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the HQGRJHQRXV RSLRLG PRQRDPLQH FDQQDELQRLG Ȗ-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and has been a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.4

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“…It is noteworthy that others (Hamm & Knisely, 1987) did not report such potentiation of analgesia produced by water immersion. It is likely that this difference in results stems from differences in procedures.…”

Section: Discussionmentioning

confidence: 93%

“…However, cold-water immersion was found to produce reductions in core temperature in pups that were inversely correlated with age (Hamm & Knisely, 1987). If a reduction in core temperature would therefore cause the analgesic response, 3-day-old pups should display more analgesia following immersion in water than older animals.…”

Section: Discussionmentioning

confidence: 94%

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Development of water‐immersion produced analgesia

Stolberg

Frenk

1995

Developmental Psychobiology

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Nociceptive and antinociceptive systems change dramatically during the first 10 days of life in rats. The present studies sought to determine whether exposure to water stress can produce analgesia during this period, and when in the ontogeny changes in magnitude and duration of such stress-induced analgesia occur. It was found that exposure to water reliably induced analgesia as early as 3 days postnatally. This analgesia increased in magnitude and duration at the age of 17-20 days, when supra-spinal descending inhibition develops, and depended on the temperature of the water and duration of exposure.

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Ontogeny of an endogenous, nonopioid and hormonally mediated analgesic system

Cited by 18 publications

References 40 publications

Swim‐stress‐induced antinociception in young rats

Swim‐stress‐induced antinociception in young rats

Stress-induced analgesia

Development of water‐immersion produced analgesia

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