2011
DOI: 10.1038/pr.2011.7
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Ontogeny of angiotensin-converting enzyme 2

Abstract: INTRODUCTION:This study examined the temporal expression of angiotensin (ang)-converting enzyme 2 (ace2) during renal, heart, lung, and brain organogenesis in the mouse. RESULTS: We demonstrate that kidney ace2 mRNa levels are low on embryonic day (e) 12.5, increase fourfold during development, and decline in adulthood. In extrarenal tissues, ace2 mRNa levels are also low during early gestation, increase in perinatal period, and peak in adulthood. The lung shows the highest age-related increase in ace2 mRNa le… Show more

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Cited by 48 publications
(40 citation statements)
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“…Affinity of SARS-CoV-2 for ACE-2 is approximately 10-20 times higher than SARS-CoV-1, which could explain higher infectivity of SARS-CoV-2 [28]. ACE-2 is found on apical membranes of nasal, oral, nasopharyngeal and oropharyngeal mucosal epithelium, alveolar epithelium, endothelial cells of blood vessels and heart, renal tubules, and enterocytes in small intestine [29]. CD-147 (target for antibody, Meplazumab) and glucose regulated protein-78 are newly described receptors of SARS-CoV-2 for cellular entry [30,31].…”
Section: Pathogenesis Of Covid-19mentioning
confidence: 99%
“…Affinity of SARS-CoV-2 for ACE-2 is approximately 10-20 times higher than SARS-CoV-1, which could explain higher infectivity of SARS-CoV-2 [28]. ACE-2 is found on apical membranes of nasal, oral, nasopharyngeal and oropharyngeal mucosal epithelium, alveolar epithelium, endothelial cells of blood vessels and heart, renal tubules, and enterocytes in small intestine [29]. CD-147 (target for antibody, Meplazumab) and glucose regulated protein-78 are newly described receptors of SARS-CoV-2 for cellular entry [30,31].…”
Section: Pathogenesis Of Covid-19mentioning
confidence: 99%
“…Moreover, ACE2 genetic variants have been associated with both essential hypertension and coronary heart disease (CHD), whilst they act as disease modifiers of both hypertrophic and dilated cardiomyopathies [31]. Concerning development, it was shown that ACE2 protein levels and activity are high during gestation and decline postnatally [32].…”
Section: Angiotensin-converting Enzyme 2 (Ace2)mentioning
confidence: 99%
“…In the in silico analyses, no binding site for transcription factors were found in the region of these two polymorphisms. ACE2 gene and protein expression and enzymatic activity are developmentally regulated in a tissue-specific manner 32 in animal experiments. Relatively high ACE2 protein levels and enzymatic activity observed during gestation in mouse models may play a role in kidney, lung, brain and heart organogenesis.…”
Section: Discussionmentioning
confidence: 99%