1989
DOI: 10.1203/00006450-198905000-00022
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Ontogeny of Epidermal Growth Factor Receptor/Kinase and of Lipocortin-1 in the Ovine Lung

Abstract: ABSTRACT. We have examined the ontogeny and distribution of the epidermal growth factor receptorlkinase (EGF receptor) and of lipocortin-1, a major cellular substrate of the EGF receptor, in a developmental series of 13 normal ovine fetal lungs (44-145 d of gestation) using the peroxidase anti-peroxidase technique with two extensively characterized polyclonal antibodies recognizing the EFG receptor and one polyclonal antibody recognizing lipocortin-1. Immunoreactive EGF receptorlkinase and lipocortin-1 were de… Show more

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Cited by 33 publications
(10 citation statements)
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“…Receptors for EGF and its fetal form, transforming growth factor-a, are widely distributed in fetal tissues including the lung and specifically the alveolar type I1 cells (37)(38)(39). This suggests that EGF/transforming growth factor-a plays a role in fetal development.…”
Section: Fie 4 Light Microsco~ic Comparison Of Lung Parenchyma In Rmentioning
confidence: 99%
“…Receptors for EGF and its fetal form, transforming growth factor-a, are widely distributed in fetal tissues including the lung and specifically the alveolar type I1 cells (37)(38)(39). This suggests that EGF/transforming growth factor-a plays a role in fetal development.…”
Section: Fie 4 Light Microsco~ic Comparison Of Lung Parenchyma In Rmentioning
confidence: 99%
“…In human lung, immunoreactive EGF was detected in nonmucous cells of tracheal and bronchial glands, but was absent from the distal budding portion of the developing lung, suggesting a role for growth factors other than EGF in distal remodeling in human lung development (16). In developing sheep, EGF-R have been localized by immunohistochemistry to the upper airways where colocalization of a novel ligand, lipocortin-1, for this receptor has been reported (10).…”
Section: Morphologymentioning
confidence: 99%
“…In late gestational human lung, immunoreactive EGF is limited to nonmucous cells of the submucosal glands of the upper airways (1 6). In fetal sheep, a novel alternative EGF-R ligand, lipocortin-1, has been immunolocalized in airway epithelium (10).…”
mentioning
confidence: 99%
“…Interestingly, in those cases where the proteins have been localized by immunohistochemical techniques, they exhibit distinctive cellular distributions [23,24], indicating specialized roles. Neutralizing antibodies provide a simple method for probing function, by allowing one to inactivate existing protein and test the effect of the perturbation on the system.…”
Section: Discussionmentioning
confidence: 99%