Ontogeny of Insulin-Like Growth Factor-Binding Protein-1, −2, and −3: Quantitative Measurements by Radioimmunoassay in Human Fetal Serum

Bang, Peter; Westgren, Magnus; Schwander, J; Blum, Werner; Rosenfeld, Ron G.; Stangenberg, Magnus

doi:10.1203/00006450-199410000-00020

Cited by 64 publications

(44 citation statements)

References 34 publications

(56 reference statements)

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“…IGFBP-3 is the primary circulating IGFBP in the second half of pregnancy, as it is in the adult non-pregnant circulation. The increase in IGFBP-3 with gestation has been documented previously (Bang et al 1994b, Langford et al 1994, although one study demonstrated no change with gestation (Giudice et al 1995). In this study we have documented a concomitant increase in ALS levels.…”

Section: Discussionsupporting

confidence: 59%

“…IGFBP-3, ALS and IGF-I, and their association in the 140 kDa complex, increased with gestational age during the second half of pregnancy. This increase in total IGF-I (Bennett et al 1983, Ashton et al 1985, Lassarre et al 1991, Verhaeghe et al 1993, Bang et al 1994b) and the free form of IGF-I (Hasegawa et al 1995) has previously been observed. IGFBP-3 is the primary circulating IGFBP in the second half of pregnancy, as it is in the adult non-pregnant circulation.…”

Section: Discussionmentioning

confidence: 99%

“…Certainly IGF-I and IGFBP-3 also appear to be regulated in a coordinated manner, increasing with gestational age with a significant positive relationship to parameters of fetal growth (Fant et al 1993). In contrast, circulating IGFBP-1 and IGFBP-2 levels are higher than in the adult circulation (Wang & Chard 1992, Blum et al 1993, Schwander & Mary 1993, Bang et al 1994b) and correlate inversely with IGF-I levels (Fant et al 1993) and with birthweight (Verhaeghe et al 1993, Giudice et al 1995.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of insulin-like growth factor-binding protein-3 ternary complex formation in pregnancy

Lewitt

Scott²,

Clarke³

et al. 1998

Journal of Endocrinology

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The IGFs are believed to be important in pregnancy and are implicated in the pathophysiology of pre-eclampsia. In adults the IGFs circulate primarily with IGF-binding protein-3 (IGFBP-3) and an acid-labile glycoprotein (ALS) in a 140 kDa complex which limits IGF bioavailability. Less than 10% of IGFBP-3 is in lower molecular weight forms. We have investigated the developmental regulation of the IGF/IGFBP system in normal and pre-eclamptic pregnancies with particular emphasis on the IGFBP-3 ternary complex. Circulating levels of IGF-I, IGFBP-3 and ALS, and their degree of association in the ternary complex in the fetus increased with gestational age. In neonatal serum from deliveries <35 weeks' gestation IGFBP-3 was predominantly in 30-50 kDa form(s) and ALS was a limiting factor for ternary complex formation. In serum from deliveries >35 weeks both ALS and IGFs were limiting but approximately 25% of IGFBP-3 was unable to form the ternary complex even in the presence of excess ALS and IGF-I. Serum IGFBP-1, -2 and -6 concentrations tended to decrease with increasing gestational age. In pre-eclamptic pregnancies, amniotic fluid IGFBP-2, -3 and -6 levels decreased with gestational age while IGFBP-1 levels did not show the normal decline. We speculate that the endocrine IGF system develops in the fetus during the third trimester of pregnancy when ALS levels increase.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of insulin-like growth factor-binding protein-3 ternary complex formation in pregnancy

Lewitt

Scott²,

Clarke³

et al. 1998

Journal of Endocrinology

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“…4), which are on average 10 ng/mL compared to the average of >50 ng/mL measured in utero at a postmenstrual age of 23–30 weeks (23, 60,S85,S86).…”

Section: Loss Of Igf‐1 After Preterm Birthmentioning

confidence: 89%

“…Normal intrauterine IGF ‐1 concentrations obtained from the umbilical cord with cordocentesis over 18–42 weeks of gestational age ( GA ) (black circles) (n = 174) 23, 60 compared to preterm infants of matched postmenstrual ages (red dots) (S86,S87).…”

Section: Loss Of Igf‐1 After Preterm Birthmentioning

confidence: 99%

Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

et al. 2016

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Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed the role of IGF‐1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF‐1 deficiency in preterm morbidities.ConclusionThere is a rationale for clinical trials to evaluate the potential benefits of IGF‐1 replacement in very preterm infants.

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Growth Hormone Bioactivity and Levels of Growth Hormone, Growth Hormone–Binding Protein, Insulinlike Growth Factor I, and Insulinlike Growth Factor–Binding Proteins in Premature and Full-term Newborns During the First Month of Life

Radetti

Bozzola

Paganini³

et al. 1997

Arch Pediatr Adolesc Med

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Ontogeny of Insulin-Like Growth Factor-Binding Protein-1, −2, and −3: Quantitative Measurements by Radioimmunoassay in Human Fetal Serum

Cited by 64 publications

References 34 publications

Regulation of insulin-like growth factor-binding protein-3 ternary complex formation in pregnancy

Regulation of insulin-like growth factor-binding protein-3 ternary complex formation in pregnancy

Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

Growth Hormone Bioactivity and Levels of Growth Hormone, Growth Hormone–Binding Protein, Insulinlike Growth Factor I, and Insulinlike Growth Factor–Binding Proteins in Premature and Full-term Newborns During the First Month of Life

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