1995
DOI: 10.1002/cne.903600310
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Ontogeny of the striatal neurons expressing neuropeptide genes in the human fetus and neonate

Abstract: The distribution patterns of neurons expressing mRNAs for four neuropeptides in the human striatum were studied during ontogeny by the use of in situ hybridization. The results of our study demonstrate that somatostatin, enkephalin, dynorphin, and substance P mRNAs are present in striatal neuronal populations from week 12 of fetal life. Each neuronal population undergoes a specific differentiation. Neurons containing somatostatin mRNA are scattered throughout the caudate-putamen up until birth. Neurons contain… Show more

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Cited by 39 publications
(32 citation statements)
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“…The protocol used has been described previously (6). Briefly, antisense and sense radiolabelled cRNA probes were prepared by in vitro transcription of the DNA template from plasmid pCMV5 constructs containing the cDNA encoding D2 receptor (2300 bp).…”
Section: In Situ Hybridizationmentioning
confidence: 99%
“…The protocol used has been described previously (6). Briefly, antisense and sense radiolabelled cRNA probes were prepared by in vitro transcription of the DNA template from plasmid pCMV5 constructs containing the cDNA encoding D2 receptor (2300 bp).…”
Section: In Situ Hybridizationmentioning
confidence: 99%
“…Opioid receptors (KORs) are widely expressed in the CNS and are specifically activated by endogenous opioids derived from prodynorphin (Chavkin et al, 1982). KORs and dynorphin mRNA initially appear during early embryonic development in both mouse and human CNS (Brana et al, 1995;Zhu et al, 1998). Dynorphin has been shown to inhibit excitatory transmission in the CNS either when exogenously applied (Castillo et al, 1996;Simmons and Chavkin, 1996;Iremonger and Bains, 2009) or endogenously released (Wagner et al, 1993;Iremonger and Bains, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Preproenkephalin is primarily expressed in striatal medium spiny projection neurons which comprise the indirect pathway innervating the globus pallidus, whereas PDYN is primarily expressed in the direct pathway to the substantia nigra. 53 Imbalance of these striatal output circuits is normally related to motor disturbances. Although prenatal marijuana exposure has been associated with increased tremors in newborns, this impairment disappears with increasing age (for a review see 52 ).…”
Section: Discussionmentioning
confidence: 99%
“…The PENK and PDYN gene expression had been documented to have a differential expression in the striatal patch and matrix compartment; both genes have a higher expression in the patch vs matrix. 53 Measurements were made separately on the patch (high expressing islands) and matrix compartment (low expressing surrounding area) by setting a threshold in optical density. The region with optical density above threshold was measured as patch and below as matrix compartment.…”
Section: Methodsmentioning
confidence: 99%