Onychopapilloma Presenting as Leukonychia: Case Report and Review of the Literature

Halteh, Pierre; Magro, Cynthia M.; Scher, Richard K.; Lipner, Shari R.

doi:10.1159/000448105

Cited by 19 publications

(11 citation statements)

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“…It was first described by Baran and Perrin in 1995, 3 with a series of four patients who presented with the typical clinical appearance of longitudinal erythronychia. Since then, approximately 20 reports, describing a total of 205 cases, have been published on this diagnosis [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] (see Table 2). Atypical appearances, including longitudinal melanonychia, have been further described, especially in patients with pigmented skin.…”

Section: Discussionmentioning

confidence: 99%

“…3 Subsequent reports have described diverse presentations, including longitudinal melanonychia, longitudinal leukonychia, yellow-brown chromonychia, splinter hemorrhages, distal nail plate fissuring, and onycholysis. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] It could easily mimic worrisome diagnoses, including melanoma and squamous cell carcinoma. Misdiagnosis could cause significant patient distress and anxiety.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

et al. 2021

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Background: Onychopapilloma is a benign tumor of the distal nail matrix and proximal nail bed with heterogeneous clinical presentations. It poses a diagnostic challenge because it could mimic subungual malignancies and inflammatory conditions. Clinical, onychoscopic, and histopathological clues play critical roles in diagnosis.Methods: We performed a retrospective chart review of onychopapilloma cases collected over 10 years, and characterized the clinical, onychoscopic, and histopathological features of onychopapilloma at an academic institution.Results: We obtained 17 biopsy-confirmed cases of onychopapilloma. Among our cases, we found manifestation of onychopapilloma as longitudinal erythronychia, longitudinal leukonychia, yellow-brown chromonychia, and longitudinal melanonychia.Long longitudinal or short splinter hemorrhages may be present. Distal fissuring with V-shaped notch, subungual keratotic mass, and onycholysis are other discernable features. Histopathological features include papillomatosis, epidermal hyperplasia, acanthosis of the distal nail bed, premature keratinization, matrix metaplasia, hyperkeratosis, and splinter hemorrhages; histopathological signs of malignancy were not observed in any of our cases.Conclusions: Onychopapilloma has polymorphic clinical and morphological features.Onychoscopic and histopathological studies are important to help exclude malignant mimickers. Consider onychopapilloma in the differential diagnoses of a monodactylous longitudinal streak in the nail, especially on the left thumb of an adult female.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

et al. 2021

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“…Onychopapilloma is the most common cause of localized longitudinal erythronychia (LLE), which sometimes manifests as leukonychia 4,8 or melanonychia 6,9 . Distal subungual hyperkeratosis is one of the most significant clinical signs of onychopapilloma; splinter hemorrhages, onycholysis and distal splitting also accompany the disease occasionally.…”

Section: Discussionmentioning

confidence: 99%

“…It commonly affects a single nail, mostly on the thumb, with longitudinal erythronychia beginning from the nail matrix and extending to the onychocorneal band 2 . Since the naming of the disease was finalized in 2000 by Baran and Perrin 3 , there have been only a limited number of reports on the disease 2,4,5 , and its characteristics have not been fully understood yet. To the best of our knowledge, only four cases have been reported in the Korean literature 6,7 .…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Onychopapilloma Presenting as a Longitudinal Erythronychia

Park

2020

Ann Dermatol

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Onychopapilloma is a rare benign neoplasm of the nail bed and the distal matrix. It is the most common cause of monodactylous localized longitudinal erythronychia. Splinter hemorrhage, onycholysis or distal splitting are usually accompanied due to the subungual keratotic growth located in the corresponding linear streak. A 50-year-old female was referred for the evaluation of 1-mm width of erythematous band on the left thumbnail. Distal onycholysis and splinter hemorrhages were seen along the streak with a thread-like horny papule beneath the edge of the nail plate. On histopathologic examination, papillomatosis and acanthosis were observed in the distal nail bed epithelium. The upper layers of the nail bed epithelium showed matrix metaplasia. The nail plate specimen revealed subungual hyperkeratosis with focal hemorrhage. The histopathological findings confirmed the clinical diagnosis of onychopapilloma. Herein, we report a rare case of onychopapilloma presenting as a longitudinal erythronychia. (Ann Dermatol 32(1) 74∼76, 2020

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“…Longitudinal erythronychia is the most common presentation of onychopapilloma but it may have different clinical presentations like melanonychia, and leukonychia. [3,4]. Onychopapilloma can also present with splinter hemorrhages without any other lesion.…”

Section: Sirmentioning

confidence: 99%