Oocyte competence in in vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case–control study

Shebl, Omar; Sifferlinger, Ida; Habelsberger, Alwin; Oppelt, Peter; Mayer, RB; Petek, Erwin; Ebner, Thomas

doi:10.1111/aogs.12941

Cited by 46 publications

(47 citation statements)

References 37 publications

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“…Advanced maternal age also results in an increase of oocyte chromosomal abnormalities, which leads to a decline in the oocyte quality and dysontogenesis [6]. Diseases, such as moderate to severe endometriosis, decrease the ovarian reserve function, affect the oocyte quality and embryo development [7]. Several studies have demonstrated, short protocol may result in fewer number of oocytes retrieved and fewer good quality embryos [8,9], which may be a reason why rate of no good quality embryos was highest in the short protocol group.…”

Section: Discussionmentioning

confidence: 99%

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

Chu¹,

Shu²,

Zhang³

et al. 2019

Preprint

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Background: The aim of this study was to clarify related factors of no good quality embryos in IVF/ICSI cycle so as to improve the IVF/ICSI outcome. Methods: Data of Day 3 embryos and patients of 2518 cycles from January 2012 to December 2016 were analyzed in this study. A binary logistic regression model was conducted to examine the factors which led to no good quality embryo in one cycle.Results: The incidence of no good quality embryo in one cycle was 13.3%. Number of oocytes, fertilization methods, stimulation protocol, and fertilization rate were significant in logistic regression analysis. Further analysis showed significant correlations between increasing intracellular fragmentation and the following parameters: number of oocytes, fertilization rate, and infertility diagnosis; slow growing embryos: number of oocytes, fertilization rate, and fertilization methods; embryos with asymmetric cleavage: number of oocytes, fertilization rate, fertilization methods, female age, and male age; compound causes: number of oocytes, fertilization rate, infertility duration, stimulation protocol, and fertilization methods.Conclusions: The results suggested that gamete poor quality is the main reason for the embryo quality decline, which underlines the importance to improve gamete quality and eventually the fertility outcome in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

Chu¹,

Shu²,

Zhang³

et al. 2019

Preprint

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“…However, Pop-Trajkovic et al [15] found a negative correlation between the LBR in IVF-ICSI and the severity of endometriosis. Moreover, Shebl et al [16] showed that endometriosis rAFS stage IV was associated with significantly worse-quality oocytes than stages I-III (p < 0.01).…”

Section: Discussionmentioning

confidence: 99%

Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis

Roux

Perrin

Mancini

et al. 2017

J Assist Reprod Genet

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“…Частота его встречаемости среди пациенток, страдающих бесплодием, составляет до 35-50% [3]. Данная патология широко распространена, в том числе среди женщин репродуктивного возраста (до 15%) [19,21]. Эндометриоз -заболевание женской репродуктивной системы, при котором эндометрий разрастается за пределами матки.…”

“…В нормальных условиях шпиндельное устройство ооцита должно быть компактным, образованным дискретными шпинделями, основным структурным компонентом которых является димер, со-стоящий из субъединиц α-и β-тубулина. Нарушение мейотического шпинделя приводит к аномальным выравниванию, выделению гомологичных хромосом и оплодотворению [19]. В последнее время морфология шпинделя стала маркером качества ооцитов.…”

Section: Endometriosis and Oocytes (A Review)unclassified

Endometriosis and oocytes (a review)

Trubitsyna¹,

Асатурова²,

Adamyan³

2018

Probl. reprod.

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Objective-to present the systematic analysis of the data of modern literature on the effect of endometriosis on oocytes and markers of their quality. Material and methods. The review contains data from foreign studies presented in the electronic database of Pubmed for the last 3 years. Results. Analysis of literature data showed that endometriosis adversely affects the quality of the oocyte and negatively correlates with the potential for the embryo development. Conclusion. Infertility of patients with endometriosis is associated with a decrease in the quality of oocytes, rather than with an endometrial medium or susceptibility. However, the observations are still controversial and require more careful consideration of disputed points and a deeper analysis.

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Oocyte competence in in vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case–control study

Abstract: Endometriosis patients, in particular those with severe endometriosis, present lower-quality oocytes. Once fertilized, no impairment of further preimplantation embryo development and pregnancy outcome right up to healthy live birth rate has to be expected.

Cited by 46 publications

References 37 publications

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis

Endometriosis and oocytes (a review)

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