Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

Inoue, Taketo; Ono, Yukiko; Yonezawa, Yukiko; Oi, Michinobu; Kobayashi, Naomi; Kishi, Junji; Emi, Nobuyuki

doi:10.4236/ojog.2013.31a036

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…The procedure involves surgically removing eggs from a woman's ovaries, combining them with sperm in the laboratory, and returning them to the woman's body or donating them to another woman [32]. Herbal medicine may use as an adjunct to ART in women by an improvement in oocyte quality [20,33] and ovarian function [33]. A study by Ushiroyama T, Yokoyama N [20] found that macrophageactivating Chinese mixed herbs (MACH) were safe in improving ISSN: 2581-3846 the reproductive outcomes in patients who had previously failed ART due to low embryonic quality.…”

Section: Discussionmentioning

confidence: 99%

Herbal Treatment for Infertility in Women: A Systematic Review

Isa¹,

Rashidi²,

Zaip³

et al. 2022

JCNRC

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Infertility is a disease of the male or female reproductive system defined by the failure to achieve pregnancy after 12 months or more of regular unprotected sexual intercourse. This study aimed to systematically review the mechanism, benefits and causes of using herbal treatment in treating infertile women of reproductive age. The search for suitable studies was carried out using Google Scholar, PubMed, Scopus and Science Direct using the search string “Herbal Treatment'' AND (“Infertility Women” OR “Infertility Female” AND (“Mechanism” OR “benefits” OR “cause”). The inclusion criteria were herbal treatment, herbal medicine or alternative treatment and women in the reproductive age. The exclusion criteria were men, older women (beyond reproductive age) and females before menarche. A total of 7 articles were systematically reviewed and appraised. The herbal treatment of interest includes Huoxue Xiaoyi Granule (HXG), Bushen Zhuyun Granule (BZG), Dan’e mixture, Ziyin recipe (ZR), Liuwei Dihuang Granule (LDG), Erzhi Tianghui Granule (ETG), Jiutengzhuyu tablets and Macrophage – activating Chinese mixed herbs (MACH). The herbal treatments had many benefits such as to improve female infertility in terms of increasing the number of high-quality oocytes and embryos, improving follicular development, ovulation, clinical pregnancy rates, blood circulation, clinical symptoms, live birth rate and endometrial receptivity. Many evidence-based traditional Chinese medicine practices were made. Before conducting more investigations, closer monitoring, toxicology studies, standardized dosage and extract used, adequate design of multicentred, randomized, parallel-controlled and blinded trials are required to deliver improved evidence for future research.

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Section: Discussionmentioning

confidence: 99%

Herbal Treatment for Infertility in Women: A Systematic Review

Isa¹,

Rashidi²,

Zaip³

et al. 2022

JCNRC

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“…Briefly, long, short, or gonadotropin-releasing hormone (GnRH)-antagonist protocols were used depending on the patient. In poor responders who have ≤2 follicles even if they were injected with human menopausal gonadotropin (hMG; ASKA Pharmaceutical Co., Tokyo, Japan) several times before during previous infertility treatment, including timing treatment or artificial insemination with sperm from the patient's husband, in combination with herbal medicine, clomifene citrate (50 mg Spacromin tablet, Pola Pharma Inc., Tokyo, Japan) and hMG were used for ovarian stimulation [ 20 ]. A GnRH analogue acetate (Fuji Pharma Co., Tokyo, Japan), hMG, and a GnRH antagonist (Cetrotide, Shionogi & Co., Osaka, Japan) were used in each protocol.…”

Section: Methodsmentioning

confidence: 99%

Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Inoue

Yonezawa²,

Sugimoto³

et al. 2016

Clin Exp Reprod Med

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ObjectiveThe decision to use in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), or split insemination (IVF-ICSI) in the first cycle is based on the number of motile sperm. Hence, total fertilization failure (TFF) often occurs during IVF cycles, despite normozoospermia. To investigate whether the cumulative motile swim-up spermatozoa percentage at 22 hours post-insemination (MSPPI) is an indicator for ICSI, we analyzed TFF, fertilization, blastocyst development, chemical pregnancy, clinical pregnancy, and live birth rates.MethodsThis prospective study was performed using data obtained from 260 IVF cycles. At 22 hours after insemination, the remaining swim-up spermatozoa were observed and divided into six groups according to MSPPI (<10%, 10% to <30%, 30% to <50%, 50% to <70%, 70% to <90%, and 90% to 100%).ResultsRegardless of the ejaculated motile sperm concentration (0.6–280×106/mL motile spermatozoa), the incidence of TFF significantly increased when MSPPI was <10%, and the fertilization rate significantly decreased when MSPPI was <30%. We found that cumulative MSPPI correlated with the cumulative fertilization rate (Spearman correlation, 0.508, p<0.001). Regarding embryo development, we observed no significant differences in the rates of blastocyst development, chemical pregnancy, clinical pregnancy, or live birth among all groups.ConclusionOur findings suggest that MSPPI is a viable indicator for split IVF-ICSI and ICSI. Taken together, by employing the MSPPI test in advance before IVF, ICSI, or split IVF-ICSI cycles, unnecessary split IVF-ICSI and ICSI may be avoided.

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“…Oocytes were inseminated by IVF or ICSI. ICSI was performed as described previously [16]. In brief, spermatozoa were selected by hyaluronic acid (HA).…”

Section: Ovarian Stimulation/in Vitro Fertilisation/intracytoplasmicsmentioning

confidence: 99%

Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

Inoue¹,

Ono²,

Yonezawa³

et al. 2014

OJOG

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The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen-thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET (−) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(−)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(−)/SEET(−) (22.4%, 22.4% and 18.4%; P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(−), PSL(−)/SEET(+) and PSL(−)/SEET(−) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively; P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.

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Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

Cited by 4 publications

References 26 publications

Herbal Treatment for Infertility in Women: A Systematic Review

Herbal Treatment for Infertility in Women: A Systematic Review

Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

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