Op-123 Evaluation of Atrial Conduction Abnormalities and Left Atrial Mechanical Functions in Patients With Subclinical Thyroid Disorders

Öztürk, Sezgin; Dikbaş, Oğuz; Baltaci, Davut; Özyaşar, Mehmet; Erdem, Abdullah; Ayhan, Semiha; Özlü, Fatih; Alçelik, Aytekin; Tosun, Mustafa; Yazıcı, Mehmet

doi:10.1016/s0167-5273(12)70067-0

Cited by 9 publications

(21 citation statements)

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“…When comparing our two groups, LA proved to be significantly larger in the low T3 group. This data pertain to the conclusions of Ozturk et al indicating that the mechanical and electromechanical function of LA is affected in subclinical thyroid disorders [17]. Moreover, a significant decrease in the E/E 0 ratio, septal E 0 , and deceleration time in patients with low T3 state was revealed.…”

Section: Discussionsupporting

confidence: 86%

“…Blood samples were stored at 18-25 8C until a clot formed (after about 15-45 min), and serums were separated by centrifugation (1200 Â g, for 15 min), and were analyzed using the automated enzyme immunoassay analyzer AIA-2000 (Tosoh corporation, Japan). The reference intervals were as follows: 3.2-5.9 pmol/L for fT3, [9][10][11][12][13][14][15][16][17][18][19][20][21].07 pmol/L for fT4, 0.38-4.31 mU/L for TSH, and <3.2 kU/L for anti-TPO.…”

Section: Thyroid Hormone Analysismentioning

confidence: 99%

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Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

et al. 2015

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Section: Discussionsupporting

confidence: 86%

Section: Thyroid Hormone Analysismentioning

confidence: 99%

Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

et al. 2015

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“…These findings are similar to those of the other studies evaluating the LA mechanical functions in patients with SCH and especially to that of the Tadic et al study. [9][10][11][12] Larger-scale studies have demonstrated that the increase left ventricular stiffness and impaired left ventricular relaxation in patients with SCH. 25,26 These changes might have caused the reduction in LA passive emptying volume and passive emptying fraction TA B L E 5 Three-dimensional echocardiographic left atrial volume and function variables of control group and patients with SCH before and after treatment F I G U R E 1 Negative correlation between the change of left atrial active emptying fraction and change of thyroid stimulating hormone after (median 86 days) thyroid hormone replacement therapy.…”

Section: Re Sultsmentioning

confidence: 99%

“…4,5 Cardiac injury in subclinical thyroid dysfunction, especially in hypothyroidism, have received attention in the last decad. [9][10][11][12] Today, different studies have shown that RT3DE provides accurate measurement of LA volume and function and it is a viable and reproducible method for clinical benefit. 7 and two-dimensional speckle tracking in patients with SCH but real time three-dimensional echocardiography (RT3DE) has never been used in the studies at all.…”

Section: Introductionmentioning

confidence: 99%

“…A limited number of studies have investigated left atrium (LA) volume and functions with conventional echocardiography and two-dimensional speckle tracking in patients with SCH but real time three-dimensional echocardiography (RT3DE) has never been used in the studies at all. [9][10][11][12] Today, different studies have shown that RT3DE provides accurate measurement of LA volume and function and it is a viable and reproducible method for clinical benefit. Subclinical cardiac involvement with impaired LA function had been revealed by using RT3DE.…”

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confidence: 99%

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Evaluation of left atrial volume and functions by real time three‐dimensional echocardiography in patients with subclinical hypothyroidism before and after levothyroxine therapy

et al. 2019

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Background/Aims: The cardiovascular system is one of the major targets of thyroid hormones. Subclinical hypothyroidism (SCH) is a common disease that can represent "early" thyroid failure. Our aim was to evaluate left atrial (LA) volume and functions in patients with SCH using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in LA parameters after the levothyroxine treatment. Methods:In total, 44 patients with SCH and 40 age-and gender-matched controls were studied. Assessments included history, physical examination and echocardiography. All patients with SCH were followed up with replacement therapy until the euthyroid status was achieved. Results:In patients with SCH, LA total emptying volume, passive emptying volume, and passive ejection fraction were significantly reduced while LA minimal volume, active emptying volume, and active emptying fraction were significantly increased than in control group. Following the levothyroxine treatment, LA volume and function parameters were observed to be significantly improved. A negative correlation between the change of thyroid stimulating hormone (TSH) and change of LA active emptying volume and a positive correlation between the change of TSH level and change of LA passive emptying volume were found. Conclusion:It was shown that volume and functions of LA were impaired in patients with SCH. However, impaired parameters were improved after the levothyroxine treatment. These findings may be indicative of subclinical heart involvement that could lead to functional and structural changes in patients with SCH. K E Y W O R D Sleft atrial volume and function, levothyroxine therapy, real time three-dimensional echocardiography, subclinical hypothyroidism

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Der hoch-normale fT4-Spiegel ist mit Vorhofflimmern assoziiert

Dietlein

Drzezga²

2016

Nuklearmedizin

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Die manifeste und die latente Hyperthyreose sind als Risikofaktoren für Vorhofflimmern (VHF) seit langem bekannt (15). Dabei nimmt das kardiale Risiko hinsichtlich des TSH-Spiegels einen "U"-förmigen Verlauf, d. h. erniedrigte oder erhöhte TSH-Spiegel bedeuten jeweils eine Risikosteigerung. Kann ein unterer TSH-Grenzwert definiert werden? In der weltweit größten Kohortenstudie, bestehend aus 586 466 Einwohnern Kopenhagens, beschrieben Selmer et al. (16) eine Subgruppe mit "hoch-normaler Euthyreose", definiert über ein TSH von 0,2-0,4 mU/l. Diese Subgruppe besaß eine höhere Inzidenz für VHF (Risiko 1,12 bei einem 95%-Konfidenzintervall von 1,03-1,21) im Vergleich zur euthyreoten Population mit einem TSH-Spiegel von 0,4-5,0 mU/l (Risiko mit der Referenz = 1 angesetzt). Hierauf basierend wird in der AWMF-Leitlinie zur Radioiodtherapie bei benignen Schilddrüsenerkrankungen u.a. der TSH-Grenzwert von ≤ 0,4 mU/l genannt, bei dessen Unterschreiten eine Schilddrüsenautononomie bzw. eine Knotenstruma als behandlungsbedürftig interpretiert wird (8). Einschränkend ist anzumerken, dass die Daten von Selmer et al. (16) eine Assoziati

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Op-123 Evaluation of Atrial Conduction Abnormalities and Left Atrial Mechanical Functions in Patients With Subclinical Thyroid Disorders

Cited by 9 publications

References 0 publications

Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

Evaluation of left atrial volume and functions by real time three‐dimensional echocardiography in patients with subclinical hypothyroidism before and after levothyroxine therapy

Der hoch-normale fT4-Spiegel ist mit Vorhofflimmern assoziiert

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