Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

Jankauskienė, Edita; Orda, Paulius; Rumbinaitė, Egle; Žaliaduonytė-Pekšienė, Diana; Steponavičiūtė, Rasa; Krasauskienė, Aurelija; Vaškelytė, Jolanta Justina; Bunevičius, Robertas

doi:10.1016/j.medici.2015.07.004

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Conventional echocardiography and speckle tracking techniques have become the preferred examination method in clinical treatment as they are non-invasive, reproducible, and high in sensitivity and accuracy (3). However, the measurements of this method are not stable (4). …”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Jin

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the study was to investigate the cardiac magnetic resonance (CMR) imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment. Fifty-six cases of AMI patients with elective treatment by percutaneous coronary intervention (PCI) were continuously selected. Patients with an incidence of 7–10 days were treated with CMR and echocardiography to evaluate the quality of myocardial infarction, visual score method (VSM), wall motion score abnormality, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF). Patients with an incidence of 10–14 days were treated with PCI, and CMR and echocardiography were evaluated after 6 months, after which the occurrence of major adverse cardiac events (MACE) were compared. The infarction quality, VSM score and wall motion abnormality (WMA) score were significantly reduced following surgery, and the difference was statistically significant (P<0.05). Ultrasound evaluation of LVEDD, LVESD, and LVEF prior to and after surgery was compared, and the difference was not statistically significant (P>0.05). Evaluation of the magnetic resonance imaging (MRI) in LVEDD prior to surgery was increased compared with that of the ultrasound in LVEDD, whereas MRI in LVESD and LVEF was decreased compared to that of the ultrasound obtained for LVESD and LVEF. Additionally, postoperative LVEDD was reduced compared with preoperative LVEDD, whereas LVEF was increased, and the difference was statistically significant (P<0.05). However, the evaluation of LVESD using the two methods exhibited no significant change. MACE occurred in 7 (12.5%) of 56 cases. The infarction quality of patients in the MACE group following surgery indicated that VSM and WMA scores were significantly higher than the group without MACE, while LVEF was lower than the MACE group following surgery, and the difference was statistically significant (P<0.05), albeit the ultrasound results of LVEF indicated no difference. In conclusion, CMR evaluation of AMI patients with elective PCI treatment in myocardial remodeling and cardiac function were more sensitive and accurate than with cardiac ultrasound.

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Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Jin

et al. 2016

Experimental and Therapeutic Medicine

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“…In this subgroup analysis, a lower FT3/FT4 ratio was a stronger predictor of all-cause and cardiovascular mortality in patients with previous myocardial infarction ( 12 ). Another study involving 130 patients with AMI found that patients with low T3 syndrome had impaired late diastolic longitudinal strain rates and left ventricular rotation than those with normal T3, but T4 levels did not differ significantly between the 2 groups ( 33 ). Therefore, we hypothesized that patients with lower FT3/FT4 ratio in this sample might also have impaired cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction

Lang

Zhao

Fang

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background It is still not clear how free triiodothyronine (FT3) to free thyroxine (FT4) ratio affects the prognosis of acute myocardial infarction (AMI), especially the risk of heart failure (HF) subsequent AMI. Objective The purpose of this study was to see how peripheral sensitivity to thyroid hormones, as measured by the FT3/FT4 ratio, affected HF and mortality after AMI. Methods Our study was a retrospective cohort study. The primary endpoint was HF post-AMI during and after hospitalization. The secondary endpoints were all-cause death and cardiovascular death after hospitalization. Results The main sample included 3,648 AMI inpatients with a median age of 61.0 years, and 68.9% were male. In the fully adjusted model, compared with patients in the lowest Q1 of the FT3/FT4 ratio, the risk of in-hospital HF was reduced by 44% (OR 0.56, 95% CI 0.44-0.72, P trend < 0.001), the risk of out-of-hospital HF in the highest Q4 patients was reduced by 37% (HR 0.63, 95% CI 0.48-0.84, P trend = 0.001), and the risks of all-cause and cardiovascular death were also significantly reduced. The analysis of different subgroups is consistent with the overall results. Furthermore, the sensitivity analysis of the euthyroid sample of 2,484 patients was consistent with the main sample. Mediation analysis showed that altered levels of NT-proBNP were mediators between the FT3/FT4 ratio and all endpoints in our study. Conclusion The thyroid hormone peripheral sensitivity of the FT3/FT4 ratio is an independent predictor of heart failure and mortality after AMI.

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Relationship between left ventricular mechanics and low free triiodothyronine levels after myocardial infarction: a prospective study

et al. 2015

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Low free triiodothyronine (fT3) levels following acute myocardial infarction (AMI) are associated with greater impairment in cardiac mechanics compared with patients with AMI who have normal values of thyroid hormones. The objectives are to investigate left ventricular (LV) function and mechanics during a 6-month follow-up after myocardial infarction and to evaluate their prognostic implication using two-dimensional (2D) echocardiography and 2D speckle-tracking echocardiography in patients with low fT3 levels. The study design is prospective cohort study. One hundred forty patients with first-onset AMI were grouped according to serum fT3 levels: low fT3 group (fT3 <3.2 pmol/L; n = 44) and control group (fT3 >3.2 pmol/L; n = 96). Low levels of fT3 were associated with greater LV diameters and LV end-diastolic volume, and decreased systolic LV function. Systolic apical and basal rotation, peak systolic global longitudinal strain and strain rate, and LV twist and torsion were significantly decreased in the low fT3 group. The prognostic implication for predicting low fT3 levels was evaluated using ROC analysis. LV end-diastolic diameter index is the most sensitive (94.12 %), but has low specificity (37.93 %; area = 0.659, p = 0.01). By contrast, LV end-systolic volume is the most specific (94.03 %), but has low sensitivity (26.32 %; area = 0.594, p = 0.04). Low fT3 levels are significantly associated with worse LV mechanics. Low fT3 levels are important for prediction of LV structure, function, rotation, and deformation parameters during the late post-myocardial infarction period.

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Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction

Abstract: The late diastolic longitudinal LV strain rate and LV rotation evaluated by speckle-tracking echocardiography were impaired in patients with low-T3 syndrome after AMI.

Cited by 4 publications

References 22 publications

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction

Relationship between left ventricular mechanics and low free triiodothyronine levels after myocardial infarction: a prospective study

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