The article analyzes the need to create innovative manufacturing enterprises in modern conditions, and justifies their role in the development of society. The principles, priorities and strategic requirements to the innovative manufacturing enterprises in the process of economic development are analyzed. International, regional and local recommendations for the formation of innovative enterprises structures are generalized. Perspective applications of components of the fourth industrial revolution are considered. Ways of improving the innovation infrastructure and environment are examined from the scientific and theoretical and methodological point of view. Priorities, mechanisms, elements of communication, the parameters and criteria for the management of innovative manufacturing enterprises structures are identified.Index Terms: Innovative economy, innovative manufacturing enterprises, innovative structures, fourth industrial revolution, technology park, high-tech park, the future of enterprise.