Open Hardware for neuro-prosthesis research: A study about a closed-loop multi-channel system for electrical surface stimulations and measurements

Rotermund, David; Ernst, Udo; Pawelzik, Klaus

doi:10.1016/j.ohx.2019.e00078

Cited by 6 publications

(5 citation statements)

References 96 publications

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“…Similar to other neuromodulation therapies [194], researchers are also considering and exploring bi-directional and closed-loop feedback approaches for retinal [36,[195][196][197][198] and cortical [100,199] prostheses. This combination would allow prostheses to automatically adjust the stimulation parameters and improve the performance over time.…”

Section: Image Processing and Advanced Encoding Strategiesmentioning

confidence: 99%

Advances in visual prostheses: engineering and biological challenges

Borda

Ghezzi²

2022

Prog. Biomed. Eng.

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Vision is an extraordinary sense through which we can appreciate the beauty of the world we live in, gain invaluable knowledge and communicate with others using visual expression and arts. On the contrary, blindness is a threatening medical condition disrupting the life of affected people and their families. Therefore, restoring sight is one of the open challenges of our society. Today, the synergistic convergence of science and technology holds the potential to provide blind patients with artificial vision using visual prostheses: a type of implantable medical device able to reactivate visual neurons using electrical stimulation. Although clinical trials showed that vision restoration is still far away, significant technological advances make visual prostheses a valuable solution for blind patients. This review is not only a description of the state-of-the-art. Instead, it provides the reader with an update on recent developments, a critical discussion of the open challenges, and an overview of promising future directions.

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Section: Image Processing and Advanced Encoding Strategiesmentioning

confidence: 99%

Advances in visual prostheses: engineering and biological challenges

Borda

Ghezzi²

2022

Prog. Biomed. Eng.

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“…Currently, most cortical visual prostheses are primarily unidirectional or open-loop, passing the visual information from the outside world captured by the image acquisition sensors to the implanted microelectrode arrays. In the future, it is expected that a high number of microelectrodes can be implanted into the brain to provide a functional vision, and such a large number of implanted electrodes may pose several stimulation problems ( Fernandez, 2018 ; Rotermund et al, 2019 ). Therefore, we have to start reconsidering and improving our methods of cortical stimulation for example with closed-loop approaches ( Figure 1A ; Rotermund et al, 2019 ).…”

Section: Toward Personalized Closed-loop Stimulation In Cortical Visu...mentioning

confidence: 99%

“…In the future, it is expected that a high number of microelectrodes can be implanted into the brain to provide a functional vision, and such a large number of implanted electrodes may pose several stimulation problems ( Fernandez, 2018 ; Rotermund et al, 2019 ). Therefore, we have to start reconsidering and improving our methods of cortical stimulation for example with closed-loop approaches ( Figure 1A ; Rotermund et al, 2019 ).…”

Section: Toward Personalized Closed-loop Stimulation In Cortical Visu...mentioning

confidence: 99%

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Grani

Soto-Sánchez

Fimia

et al. 2022

Front. Cell. Neurosci.

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Current cortical visual prosthesis approaches are primarily unidirectional and do not consider the feed-back circuits that exist in just about every part of the nervous system. Herein, we provide a brief overview of some recent developments for better controlling brain stimulation and present preliminary human data indicating that closed-loop strategies could considerably enhance the effectiveness, safety, and long-term stability of visual cortex stimulation. We propose that the development of improved closed-loop strategies may help to enhance our capacity to communicate with the brain.

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“…Therefore, we need further procedures for fitting devices containing hundreds of electrodes in patients. A possible approach to facilitate the fitting procedures could be to develop bidirectional intracortical devices able to record the neuronal activity in response to electrical stimulation and use the recorded neural activity to optimize the stimulation parameters (Rotermund et al, 2019). Another possibility could be to use machine learning to find optimal stimulation settings (Kumar et al, 2016).…”

Section: Engineering a Wireless Intracortical Device With Hundreds Ofmentioning

confidence: 99%

Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects

2020

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The restoration of a useful visual sense in a profoundly blind person by direct electrical stimulation of the visual cortex has been a subject of study for many years. However, the field of cortically based sight restoration has made few advances in the last few decades, and many problems remain. In this context, the scientific and technological problems associated with safe and effective communication with the brain are very complex, and there are still many unresolved issues delaying its development. In this work, we review some of the biological and technical issues that still remain to be solved, including longterm biotolerability, the number of electrodes required to provide useful vision, and the delivery of information to the implants. Furthermore, we emphasize the possible role of the neuroplastic changes that follow vision loss in the success of this approach. We propose that increased collaborations among clinicians, basic researchers, and neural engineers will enhance our ability to send meaningful information to the brain and restore a limited but useful sense of vision to many blind individuals.

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Open Hardware for neuro-prosthesis research: A study about a closed-loop multi-channel system for electrical surface stimulations and measurements

Cited by 6 publications

References 96 publications

Advances in visual prostheses: engineering and biological challenges

Advances in visual prostheses: engineering and biological challenges

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects

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