Given the high efficiency of heat pipes as heat transfer devices, which work with phase changing principle (evaporation and condensation) and without requiring any external energy input, the heat pipes have been utilized for many years in several areas. However, heat transfer in heat pipes is limited by physical phenomena which appear during its operation, called heat pipe limitations; these can limit and reduce its performance. At this state, the use of nanofluids instead of conventional fluids come a solution after that Choi and Eastman (1995) confirmed the feasibility of enhancing the thermal conductivity of fluids by adding nanoparticles. This paper represents a general description of heat pipes, including a brief historical perspective, principle of operation and explanation of main heat transfer limitations. The work shows the contribution of nanofluids in pushing back the heat transfer limitations