“…The broad selectivity of the calixarenes will in fact facilitate their use as biochemical reagents for the study of multiple pathways, and the promise of using supramolecular reagents for the construction of novel biochemical assays has already been established. 36,37,40 There is also hope for improving their specificity further to the point of being useful for studies into the chemical biology of modification pathways. The structure-function relations identified here have provided us with a basic understanding of the molecular recognition determinants for these synthetic receptors.…”