Ophiopogon japonicus inhibits radiation-induced pulmonary inflammation in mice

Yao, Qingzhou; Wang, Xiaoying; Li, Jiancheng; Zhang, Jun

doi:10.21037/atm.2019.11.01

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…ShenMai injection, prepared from Panax ginseng and Ophiopogon japonicus, is used as an add-on therapy for CAD [72,73]. The main components of Ophiopogon japonicus exhibit various pharmacological activities, such as cardiovascular protection [74][75][76][77], anti-inflammation [74,76,[78][79][80], antioxidation [74][75][76]81], mitochondrial function preservation [81], apoptosis inhibition [75,81], and immunomodulation [74,77]. The extract of Ophiopogon japonicus decreased ICAM-1 and VCAM-1 to play an endothelial protective role from oxidative damage and dysfunction [82].…”

Section: Discussionmentioning

confidence: 99%

Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease

Liang

Zhang

2020

BMC Complement Med Ther

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Background Guanxin V (GXV), a traditional Chinese medicine (TCM), has been widely used to treat coronary artery disease (CAD) in clinical practice in China. However, research on the active components and underlying mechanisms of GXV in CAD is still scarce. Methods A virtual screening and network pharmacological approach was utilized for predicting the pharmacological mechanisms of GXV in CAD. The active compounds of GXV based on various TCM-related databases were selected and then the potential targets of these compounds were identified. Then, after the CAD targets were built through nine databases, a PPI network was constructed based on the matching GXV and CAD potential targets, and the hub targets were screened by MCODE. Moreover, Metascape was applied to GO and KEGG functional enrichment. Finally, HPLC fingerprints of GXV were established. Results A total of 119 active components and 121 potential targets shared between CAD and GXV were obtained. The results of functional enrichment indicated that several GO biological processes and KEGG pathways of GXV mostly participated in the therapeutic mechanisms. Furthermore, 7 hub MCODEs of GXV were collected as potential targets, implying the complex effects of GXV-mediated protection against CAD. Six specific chemicals were identified. Conclusion GXV could be employed for CAD through molecular mechanisms, involving complex interactions between multiple compounds and targets, as predicted by virtual screening and network pharmacology. Our study provides a new TCM for the treatment of CAD and deepens the understanding of the molecular mechanisms of GXV against CAD.

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Section: Discussionmentioning

confidence: 99%

Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease

Liang

Zhang

2020

BMC Complement Med Ther

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“…Ophiopogon japonicus (Thunb. ) Antitusivo, antiinflamatorio, inmunomodulador, protector pulmonar, antimicrobiano (Chen et al, 2016;Yao et al, 2019;Wang et al, 2020b).…”

Section: Nelumbo Nuciferaunclassified

Plants used to treat respiratory diseases introduced by Bolivian and Chinese immigrants in the Metropolitan Area of Buenos Aires, Argentina

Puentes¹,

Arenas²,

Hurrell³

2022

BLACPMA

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This contribution includes the registry of 28 species of medicinal plants and their derived products used to treat respiratory diseases in theMetropolitan Area of Buenos Aires, Argentina, introduced by Bolivian and Chinese immigrants. Information on these species (their assigned local uses) was obtained from interviews with local informants and from other sources, such as labels, brochures and catalogs, print and electronic. A bibliographic review was carried out on the biological activity and effects studied in order to evaluate its correspondence with the assigned local uses. The degree of visibility of the treated species was analyzed, according to their circulation in the restricted commercial circuits (Chinese and Bolivian immigrants) and the general commercial circuit. Of the total, 17 species belong to the segment of Chinese immigrants, and the remaining 11 to the Bolivian segment. The most frequently reported respiratory conditions are: "asthma", "cough", "bronchitis", "respiratory tract infections", "lung ailments". The immigrant segments play a fundamental role in the conservation of biocultural diversity in the study area.

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“…The results of this study support the use of OP-C to inhibit radiation-induced acute pulmonary inflammation. However, the effect of OC-P in ameliorating chronic radiation-induced pulmonary fibrosis remains unclear ( 9 ). The aim of this study was to assess and update the protective effects and underlying mechanisms of OP-C in ameliorating chronic radiation-induced pulmonary fibrosis in a C57BL/6 mouse model of pulmonary fibrosis.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ophiopogonin C in Ameliorating Radiation-Induced Pulmonary Fibrosis in C57BL/6 Mice: An Update Study

Yao

2022

Front. Oncol.

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BackgroundThe aim of this study was to assess and update the protective effects and underlying mechanisms of Ophiopogonin C (OP-C), a biologically active component separated and purified from Ophiopogon japonicus, in ameliorating radiation-induced pulmonary fibrosis in C57BL/6 mice administered thoracic radiation.Methods and MaterialsWe randomly divided 75 mice into five groups and administered a dose of 12-Gy whole thoracic radiation to establish a pulmonary fibrosis animal model. Mice were treated with OP-C or dexamethasone combined with or without cephalexin by daily gavage for 4 weeks. All mice were sacrificed after the completion of thoracic irradiation at 28 weeks. Serum levels of interleukin-6 and transforming growth factor-β1 (TGF-β1) were evaluated. Moreover, superoxide dismutase (SOD) levels in lung tissue were measured. The severity of fibrosis was evaluated using the hydroxyproline content of the lung tissue. The pathological changes in the five groups were detected by hematoxylin and eosin and Masson trichrome staining. Smooth muscle actin expression was detected using immunohistochemical staining. Matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteases-2 (TIMP-2) were examined by immunohistochemical staining of the lung sections, and semiquantitative analysis was used to calculate the expression of MMP-2 and TIMP-2.ResultsIrradiated mice treated with OP-C or DXE combined with or without cephalexin significantly reduced mortality in mice and fibrosis levels by 1) reducing the deposition of collagen and accumulation of inflammatory cells and fibroblasts, 2) downgrading levels of the promote-fibrosis cytokine TGF-β1, and 3) increasing SOD activity in the lung tissue compared with that of irradiated mice without treatment. However, there were no statistical differences in fibrosis levels among the irradiated mice treated with OP-C or DXE combined with or without cephalexin.ConclusionOP-C significantly ameliorates radiation-induced pulmonary fibrosis and may be a promising therapeutic strategy for this disorder.

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Ophiopogon japonicus inhibits radiation-induced pulmonary inflammation in mice

Cited by 12 publications

References 20 publications

Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease

Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease

Plants used to treat respiratory diseases introduced by Bolivian and Chinese immigrants in the Metropolitan Area of Buenos Aires, Argentina

The Effect of Ophiopogonin C in Ameliorating Radiation-Induced Pulmonary Fibrosis in C57BL/6 Mice: An Update Study

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