Ophiopogon root (Radix Ophiopogonis) prevents ultra-structural damage by SO2 in an epithelial injury model for studies of mucociliary transport

O’Brien, Denise; Morris, Mélanie; Lee, M.S; Tai, Shusheng; King, M.

doi:10.1016/j.lfs.2003.09.067

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…For example, Rehmanniae has been reported to stimulate the proliferation of osteoblasts [ 42 ]; Rhizoma Anemarhenae [ 43 ] and Drynariae Rhizoma [ 44 ] have been reported to promote bone formation; and Achyranthis bidentatae [ 45 ] and Puerariae radix [ 46 ] have been reported inhibit bone loss. The remaining ingredients of mYJ including Phellodendri cortex and Ophiopogonis root have been reported to attenuate bacterial lipopolysaccharide-induced inflammation [ 47 ] and protect frog palatal epithelial cells against sodium metabisulphite induced damage [ 48 ], respectively. The major alkaloid component of Phellodendri cortex , berberine, has been reported to modulate the post-transcriptional regulatory mechanism of the iNOS gene, inhibit the activity of COX-2 and reduce the production of PGE 2 in LPS-stimulated mouse macrophages [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Adjunctive use of modified Yunu-Jian in the non-surgical treatment of male smokers with chronic periodontitis: a randomized double-blind, placebo-controlled clinical trial

Zee

Chan

et al. 2016

Chin Med

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BackgroundYunu-Jian (YJ) is a Chinese medicine (CM) heat purging formula, which is used to reduce wei huo (stomach-heat, SH) and enrich shen yin (kidney-yin, KY). This formula is also commonly used to manage diabetes mellitus and gum/oral inflammation. The activity of YJ can be modified or refined by the addition of other CM herbs and/or minor changes to one of its five key ingredients. The aim of this study was to evaluate the adjunctive use of modified YJ (mYJ) or YJ containing additional osteoblast-stimulating and inflammation-modulating CM herbs in the non-surgical periodontal treatment of smokers with chronic periodontitis in a randomized, double-blind, prospective, placebo-controlled study.MethodsHealthy adult male smokers with untreated chronic periodontitis who showed CM syndrome of SH and KY deficiency (KYD) whilst attending a dental teaching hospital from October to December, 2005, were invited to participate in a randomized double-blind, placebo-controlled clinical trial. The trial itself involved the once-daily oral administration of a placebo or mYJ for 3 months as an adjunct to non-surgical periodontal therapy. Several periodontal parameters, including radiographic alveolar bone density, were measured by computer-assisted densitometric image analysis (CADIA) on selected sites, and CM signs of SH and KYD were followed from their baseline values to various time points up to 12 months or the end of study.ResultsTwenty-five smokers (consumed 25.0 ± 15.3 smoking-pack years, ranged 7.5–80; aged 46.3 ± 6.8 years) with periodontitis and SH and KYD were recruited (Placebo, n = 14; mYJ, n = 11). All of the participants showed good tolerance towards the CM recipe. All of the periodontal parameters had improved after 12-month follow-up, and no statistically significant differences were detected between the control group and test group, except for the higher CADIA values observed compared with the baseline at 12 months for test sites (P = 0.025). 4/3/3 test vs 14/13/13 control participants had persisting SH and KYD at 6, 9 and 12 months (P < 0.001), respectively.ConclusionsThe adjunctive use of mYJ preserved the post-treatment increases in the radiographic alveolar bone density at the study sites and led to an overall improvement in SH and KYD compared with the controls.Trial registration HKU Clinical Trial Register, HKCTR-1848 (www.hkuctr.com/Study/Show/3acbf983831244d29d50b543540bf6e9)Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0111-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Adjunctive use of modified Yunu-Jian in the non-surgical treatment of male smokers with chronic periodontitis: a randomized double-blind, placebo-controlled clinical trial

Zee

Chan

et al. 2016

Chin Med

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“…Japanese Angelica, which is used in Kampo medicine, has a reputation for its safety and quality control [42] and is thought to have a similar function to Angelica sinensis, although its pharmacological mechanism is not scientifically elucidated in detail yet. Ophiopogon Tuber is thought to have an anti-inflammatory effect and to treat dry cough and dry mouth, tongue, and throat by nourishing and moistening the lungs and the bowels [40]; a finding that is supported by the reports that Ophiopogon has anti-inflammation activity [43] and has a beneficial effect on a mouse model for Sjogren's syndrome [44] and on an epithelial injury model for studies of mucociliary transport [45]. Peony Root is often concurrently used with Angelica Root and improves blood deficiency, dissipates blood stagnation, and relieves pain [5, 36, 40].…”

Section: Discussionmentioning

confidence: 99%

A Valid Approach in Refractory Glossodynia: A Single-Institution 5-Year Experience Treating with Japanese Traditional Herbal (Kampo) Medicine

Okamoto

Chino

Hirasaki

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Glossodynia is often refractory to conventional medicine, and there is only limited evidence to guide clinicians in its management. Patients with refractory glossodynia are often introduced to Japanese traditional herbal (Kampo) medicine experts under such circumstances because Kampo medicine has become known in Japan to be effective in treating a wide variety of symptoms refractory to conventional medicine. Herein, we report our single-institution 5-year experience treating patients with Kampo medicine for primary glossodynia that was refractory to conventional medicine. We found that 69.2% of patients reported a beneficial effect of Kampo medicine on glossodynia, and the average onset of improvement was 8.0 ± 7.7 weeks after starting Kampo treatment. The top two frequently used Kampo medicines for glossodynia were seinetsuhokito and mibakuekkito among high responders who showed a decrease of severity by 50% or more. The top four most overlapped herbs among effective Kampo medicines for glossodynia were Glycyrrhiza Root, Ginseng Root, Hoelen, and Atractylodes (lancea) Rhizome, which compose an essential Kampo prescription called shikunshito. Although more research is required to further clarify the effectiveness of Kampo medicine, it has valid efficacy even in cases of glossodynia that remain incurable by conventional treatments.

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Binary chromatographic fingerprinting for quality evaluation of Radix Ophiopogonis by high‐performance liquid chromatography coupled with ultraviolet and evaporative light‐scattering detectors

Liu¹,

Lu²,

Shao³

et al. 2007

J of Separation Science

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Radix Ophiopogonis is a widely used traditional Chinese medicine. The quality of Radix Ophiopogonis available in the market varies, and some confusing or fake herbs exist. In order to improve the quality control of Radix Ophiopogonis, a novel fingerprinting method was established using HPLC coupled with UV and evaporative light-scattering detectors (ELSDs). Extraction with methanol and liquid-liquid extraction with water-saturated n-butanol were employed for the preparation of the sample solution. Chromatographic separation was performed on a Lichrospher C(18) column (250x4.6 mm id, 5.0 microm particle size) with a linear gradient elution program. UV detection at 280 nm and evaporative light-scattering detection were utilized to obtain two subfingerprinting chromatograms. A novel protocol for data processing was proposed, in order to identify and remove redundant data obtained by the two detectors, and balance the weight of the two subfingerprints on the similarity values. The method was validated and applied to quality evaluation of 16 samples of Radix Ophiopogonis and related herbs.

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Ophiopogon root (Radix Ophiopogonis) prevents ultra-structural damage by SO2 in an epithelial injury model for studies of mucociliary transport

Cited by 7 publications

References 14 publications

Adjunctive use of modified Yunu-Jian in the non-surgical treatment of male smokers with chronic periodontitis: a randomized double-blind, placebo-controlled clinical trial

Adjunctive use of modified Yunu-Jian in the non-surgical treatment of male smokers with chronic periodontitis: a randomized double-blind, placebo-controlled clinical trial

A Valid Approach in Refractory Glossodynia: A Single-Institution 5-Year Experience Treating with Japanese Traditional Herbal (Kampo) Medicine

Binary chromatographic fingerprinting for quality evaluation of Radix Ophiopogonis by high‐performance liquid chromatography coupled with ultraviolet and evaporative light‐scattering detectors

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