Ophioviruses: State of the Art

García, María Laura

doi:10.5772/29707

Cited by 7 publications

(2 citation statements)

References 58 publications

(74 reference statements)

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“…FMD is a contagious viral disease clinically characterized by lesions in the mouth and feet of cloven-hoofed animals, which has affected more than 70 animal species including cattle, pigs, sheep, goats, water buffalo, and wild ruminants ( Garcia, 2012 ; Li et al, 2021 ), and imposes burden on the economy of many countries worldwide ( Sinkala et al, 2014 ; Diaz-San Segundo et al, 2017 ). FMD virus (FMDV) is a member of the Aphthovirus genus within the Picornaviridae family.…”

Section: Introductionmentioning

confidence: 99%

Molecular evolution, diversity, and adaptation of foot-and-mouth disease virus serotype O in Asia

et al. 2023

Front. Microbiol.

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Foot-and-mouth disease (FMD) is highly contagious and affects the economy of many countries worldwide. Serotype O is the most prevalent and is present in many regions of Asia. Lineages O/SEA/Mya-98, O/Middle East-South Asia (ME-SA)/PanAsia, O/Cathay and O/ME-SA/Ind-2001 have been circulating in Asian countries. Low antigenic matching between O/Cathay strains and current vaccine strains makes the disease difficult to control, therefore, analyzing the molecular evolution, diversity, and host tropisms of FMDV Serotype O in Asia may be helpful. Our results indicate that Cathay, ME-SA, and SEA are the predominant topotypes of FMDV serotype O circulating in Asia in recent years. Cathay topotype FMDV evolves at a higher rate compared with ME-SA and SEA topotypes. From 2011 onwards, the genetic diversity of the Cathay topotype has increased substantially, while large reductions were found in the genetic diversity of both ME-SA and SEA topotypes, suggesting a trend that infections sustained by the Cathay topotype were becoming a more severe epidemic in recent years. Analyzing the distributions of host species through time in the dataset, we found that the O/Cathay topotype was characterized by a highly swine-adapted tropism in contrast with a distinct host preference for O/ME-SA. The O/SEA topotype strains identified in Asia were isolated mainly from cattle until 2010. It is worth noting that there may be a fine-tuned tropism of the SEA topotype viruses for host species. To further explore the potential molecular mechanism of host tropism divergence, we analyzed the distribution of structure variations on the whole genome. Our findings suggest that deletions in the PK region may reflect a common pattern of altering the host range of serotype O FMDVs. In addition, the divergence of host tropism may be due to accumulated structural variations across the viral genome, rather than a single indel mutation.

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Section: Introductionmentioning

confidence: 99%

Molecular evolution, diversity, and adaptation of foot-and-mouth disease virus serotype O in Asia

et al. 2023

Front. Microbiol.

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“…The Nudiviridae family, which diverged 220 MA from the well-known Baculoviridae family, comprises viruses infecting arthropods (Abd-Alla et al, 2008; Jehle et al, 2013; Thézé et al, 2011; Y. Wang et al, 2012). Integration of nudivirus sequences have been described in genome of arthropods including several insects (Bézier et al, 2015; Burand et al, 2012; R.-L. Cheng et al, 2014, 2020; S. Liu et al, 2020, 2021; Y.…”

Section: Introductionmentioning

confidence: 99%

Discovery of new endogenous viral elements in campoplegine wasps (Ichneumonidae, Campopleginae, Campoplex) suggests a widespread nudivirus domestication event

de Araujo,

Leobold,

Cariou

et al. 2023

Preprint

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Viral endogenization is a widespread phenomenon that generally results in non-functional viral elements. In parasitoid wasps, nudiviruses have been involved in three independent domestication events and play a key role in parasitism success. In Campopleginae (Ichneumonidae), endogenized ichnovirus presence is widespread, with the exception ofVenturia canescens(Ichneumonidae Campopleginae), which is known to harbour an endogenous nudivirus that enables the wasp to produce Virus-Like-Particles (VLPs). So far, in Campopleginae, the nudivirus endogenization event was an isolated case restricted toV. canescens.Using third generation sequencing technologies, microscopy and mass spectrometry, we described new cases of domesticated nudiviruses in campoplegine wasps of the genusCampoplex. We found endogenized viruses inCampoplexgenomes which belong to the Alphanudivrius genus and derive from the same endogenization event as the virus found inV. canescens,suggesting that this integration event could be much more widespread in Campopleginae than previously thought. These nudiviruses are organised in highly conserved clusters, but this organisation appears to have changed relatively to free viruses during the domestication process. We showed thatCampoplex capitatorproduces in its ovaries VLPs that are similar morphologically toV. canescensVLPs, with almost the same protein content, except for a strikingly different virulence proteins, a sign of different evolutionary paths taken to respond to distinct evolutive pressure. While ichnovirus remnants have been previously found inV. canescens, no trace of ichnovirus could be detected inCampoplexgenomes, meaning that the evolutionary history of viral integrations in Campopleginae is more complex than previously imagined.

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