Ophthalmic Drug Delivery System-A Concise Review on its Conventional and Novel Approaches

Arora, Kunal; Singh, Sumita; Chaurasia, Lovely

doi:10.24092/crps.2018.080401

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…That being said, the topical application of BVZ seems to be a non-invasive and practical procedure to treat several anterior segment diseases; however, there are some disadvantages that cannot be underestimated when common eye-drops are administered, such as the poor ocular bioavailability, due to high tear-fluid turnover rate and high nasolacrimal drainage. Novel ocular drug delivery approaches, including nanomicelles, nanoparticles [ 22 ], drug-eluting contact lenses, ocular inserts, ocular iontophoresis and ocular devices that prolong precorneal residence and enhance the bioavailability of the therapeutic agent are under study [ 23 , 24 , 25 ]. The primary goal of any ophthalmic topical drug delivery system is to improve the precorneal residence time, maintain a therapeutic drug concentration level at the target site, reduce the frequency of administration and overcome the various ocular barriers.…”

Section: Introductionmentioning

confidence: 99%

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

et al. 2021

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Bevacizumab (BVZ), a recombinant humanized monoclonal antibody, has recently been proposed as a topical application in the treatment of anterior segment neovascularization; however, as there are some disadvantages in the administration of common eye-drops, ophthalmic topical drug delivery systems are under study to improve the precorneal residence time, reducing the frequency of administration. In this work, oil-in-water and water-in-oil BVZ-loaded microemulsions are developed, able to increase their viscosity, either by the formation of a liquid-crystalline structure upon aqueous dilution, thanks to the presence of Epikuron® 200 and polysorbate 80, or by body-temperature-induced jellification for the presence of Pluronic® F127 aqueous solution as an external phase. In oil-in-water microemulsion, hydrophobic ion pairs of BVZ were also prepared, and their incorporation was determined by release studies. Microemulsions were characterized for rheological behavior, corneal opacity, in vitro corneal permeation, and adhesion properties. The studied microemulsions were able to incorporate BVZ (from 1.25 to 1.6 mg/mL), which maintained dose-dependent activity on retinal pigment epithelial ARPE-19 cell lines. BVZ loaded in microemulsions permeated the excised cornea easier (0.76–1.56% BVZ diffused, 4–20% BVZ accumulated) than BVZ commercial solution (0.4% BVZ diffused, 5% accumulated) and only a mild irritation effect on the excised cornea was observed. The good adhesion properties as well the increased viscosity after application, under conditions that mimic the corneal environment (from 1 × 103 to more than 100·× 103 mPa·s), might prolong precorneal residence time, proving these systems could be excellent topical BVZ release systems.

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Section: Introductionmentioning

confidence: 99%

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

et al. 2021

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“…To speed up the drying process, the prepared films were also placed in an oven at 40 • C. By carefully using a blade or scalper, the films were removed from Petri dishes and kept for 24 h in a desiccator. Finally, the prepared films were cut into the required sizes [3,6].…”

Section: Introductionmentioning

confidence: 99%

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study

Safhi,

Siddique,

Zaman

et al. 2023

Pharmaceuticals

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A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride (ITHC) to improve their bioavailability and, hence, improve compliance with the patients of migraines and its associated symptoms. The prepared films were evaluated for various in vitro parameters, including surface morphology, mechanical strength, disintegration test (DT), total dissolving time (TDT), drug release and drug permeation, etc., and in vivo pharmacokinetic parameters, such as area under curve (AUC), mean residence time (MRT), half-life (t1/2), time to reach maximum concentration (Tmax), and time to reach maximum concentration (Cmax). The outcomes have indicated the successful preparation of the films, as SEM has confirmed the smooth surface and uniform distribution of drugs throughout the polymer matrix. The films were found to be mechanically stable as indicated by folding endurance studies. Furthermore, the optimized formulations showed a DT of 13 ± 1 s and TDT of 42.6 ± 0.75 s, indicating prompt disintegration as well as the dissolution of the films. Albino rabbits were used for in vivo pharmacokinetics, and the outcomes were evident of improved pharmacokinetics. The drug was found to rapidly permeate across the buccal mucosa, leading to increased bioavailability of the drug: Cmax of 130 and 119 ng/mL of ITHC and EHBR, respectively, as compared to 96 (ITHC) and 90 ng/mL (EHBR) of oral solution. The conclusion can be drawn that possible reasons for the enhanced bioavailability could be the increased surface area in the form of buccal films, its rapid disintegration, and faster dissolution, which led toward the rapid absorption of the drug into the blood stream.

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“…The matrix is normally based on polymers that may be synthetic or from natural sources. The synthetic polymers most used in the preparation of orodispersible films are poly(vinylpyrrolidone) and poly(ethylene oxide), while the natural polymers include pullulans, starch, gelatin, pectin, sodium alginate, and maltodextrin (Arora, Chakraborty, 2017).…”

Section: Introductionmentioning

confidence: 99%

Starch-based orodispersible film for diclofenac release

Tamanini,

Moraes,

Amaral

et al. 2023

Braz. J. Pharm. Sci.

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The form of drug administration affects the success of treatment, since it can influence adherence of the patient to the therapy. The use of orodispersible films has emerged as a way to overcome some drawbacks of conventional methods of drug delivery, especially for patients experiencing difficulty in swallowing. These films are prepared using a matrix that incorporates the drug and contains other substances that confer the properties of the system. The present work describes the use of thermoplastic starch as a carrier for the model drug diclofenac, including film preparation and testing of its orodispersible potential. Preparation of the film employed a microwave oven to gelatinize and plasticize corn starch, with incorporation of the model drug, followed by solvent-casting. The samples were characterized using mechanical tests, analyses of water uptake and water content, and Fourier transform infrared spectroscopy. The results indicated that the film presented promising properties as an alternative system for oral drug administration, with good incorporation and distribution of the drug in the matrix. The material displayed satisfactory mechanical properties, which are crucial for this type of material, due to the need for oral administration and handling before use.

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Ophthalmic Drug Delivery System-A Concise Review on its Conventional and Novel Approaches

Cited by 3 publications

References 9 publications

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study

Starch-based orodispersible film for diclofenac release

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