In pharmaceutical research, the percutaneous route of drug has gained a great interest. Percutaneous delivery has enhanced a noval vesicular drug carrier system called transferosome introduced in 1990, which is composed of water, surfactant and phospholipid. The elasticity of vesicular transferosome is more than the standard liposome therefore well suited for the penetration into the skin. The transferosomes can be prepared by Reverse Phase Evaporation method, Modified Hand Shaking, Lipid Film Hydration Technique and Thin Film Hydration Technique. This article is focused on various drug lists which easily accommodate in transferosome. Transferosome application areas included Delivery of Insulin, Carrier for Interferons & Interlukin, Transdermal Immunization, and Carrier for Other Proteins & Peptides, Peripheral Drug Targeting, Transdermal Immunization, Delivery of NSAID, and Delivery of steroidal hormones etc. To overcome problems of systemic toxicity associated with targeting therpy, enhance treatment resolution of targeting therapies.

The main aim of this review is to focus on the various kinds of approaches which are used in ophthalmic drug delivery. Ophthalmic drug delivery system is used to treat various conditions associated with eye. The main purpose of a formulation designer is to formulate an eye formulation which could reside in the eye in an optimum concentration and for a proper duration for its proper effect. The main problem seen in the conventional dosage forms is their poor bioavailability due to fast precorneal drug loss primarily due to nasolacrimal drainage. The residence time of conventional formulations is also very less in the eye resulting into minimal advantages. In order to combat all these problems, now days the pharmaceutical scientists are very much involved in the research towards the novel approaches of ophthalmic drug delivery. The present paper enlists the important novel formulations which have been developed recently and explore their various advantages over conventional forms.

The Present Investigation was aimed to develop a Polyherbal tablet formulation for effective treatment of diabetes mellitus. Polyherbal tablets containing various Herbal extracts were prepared using different super disintegrants in varying concentrations to achieve minimum disintegration time. Pre-compression Parameters for all blends were within acceptable range of pharmacopoeial specifications. Formulation F4 showed minimum disintegration time of 14.20 minutes. Hence, it was selected as an optimised formulation and subjected to stability study. Stability study results revealed that, formulation F4 was a stable formulation having better disintegration time and % friability and could be used for effective treatment of diabetes mellitus.

The present work aimed to produce Curcumin based nanoliposomes that nanoliposome can target the site via the brain in a controlled manner. Nanoliposomes are important in controlling the carriage; Curcumin which is an active constituent of curcuminoids thus also provides an effective treatment for the central nervous system and plays a crucial role. The interaction of the drug was ruled out by FT-IR studies and no incompatibility and lipids and surfactant. To optimize the formulation, factors affecting the physical appearance of Nanoliposomes were investigated. Curcumin-loaded Nanoliposomes were formulated using cholesterol by physical dispersion method and characterized for particle size, drug content, stability, production yield. Prepared nanoliposomes gave the better physical, morphological concerning the concentration of the lipids, surfactant, and ratio of lipid and surfactant. Six different formulations of Nanoliposomes F1-F6 were formulated to obtain the optimized formulation. The TEM (Transmission Electron Microscopy) of Nanoliposomes showed that they were rounded in shape and porous in texture. In-vitro drug release of formulation indicates that formulation F6 was selected as an optimized formulation for incorporation into the nanoliposomes among all the six formulations and liposome showed drug release in a controlled manner at the end of 10 hours. Keywords: Curcumin, Nanoliposomes, Physical Dispersion Method, Brain Targeting, Blood-Brain Barrier, Cholesterol, Bioavailability, In vitro Release.