Ophthalmic effects of low-energy laser irradiation

Belkin, Michael; Schwartz, Michal

doi:10.1016/0039-6257(94)90156-2

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…Unchecked mercantilism by some manufactures and absence of sound scientific methodology behind many studies were important causes for the initial stagnation of the field and caused long-lasting discredit. 8 Other obstacles have been much more fundamental. Until recently, low-energy lasers had not been shown to induce indisputable clinical effects, as they were either too small, transitory, or questionable.…”

mentioning

confidence: 99%

Photo-Infrared Pulsed Bio-Modulation (PIPBM): A Novel Mechanism for the Enhancement of Physiologically Reparative Responses

Santana-Blank

Rodríguez–Santana

Santana-Rodríguez

2005

Photomedicine and Laser Surgery

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mentioning

confidence: 99%

Photo-Infrared Pulsed Bio-Modulation (PIPBM): A Novel Mechanism for the Enhancement of Physiologically Reparative Responses

Santana-Blank

Rodríguez–Santana

Santana-Rodríguez

2005

Photomedicine and Laser Surgery

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“…I had been reading about studies using low-energy lasers to induce non-thermal photochemical effects. [1][2][3][4] So this experience led me to ponder about how selective light absorption by water might be used to target, non-thermally and non-invasively, advanced systemic cancer and other complex diseases. 5 A major obstacle for cancer drugs aiming at single molecular targets to minimize nonspecific toxicity has been that clinical response is often transitory and followed by relapse.…”

Section: Conference Proceedingmentioning

confidence: 99%

Water-light interaction: A novel pathway for multi hallmark therapy in cancer

Santana-Blank¹,

Rodríguez–Santana

Reyes

et al. 2013

Int J Cancer Ther Oncol

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Laser photobiomodulation (LPBM) has been proposed as a multi-target (multi-hallmark) therapy for cancer and other complex diseases based on an approach that aims to substitute and/or complement metabolic energy pathways through oxygen-dependent (e.g., cytochrome c oxidase (CcO)) and/or oxygen-independent (e.g., light-water interactions (e.g., F0-F1 motors)) mechanisms with critical signaling pathways in primarily aqueous media. Cellular and molecular bases for water-mediated, long-range, energy supplementation aimed at inducing and modulating physiologically reparative processes, including apoptosis, have been previously presented through a mechanism termed Photo Infrared Pulsed Biomodulation (PIPBM). Water's role as an oscillator in LPBM has also been documented. These ideas were recently complemented by integrating the role of the quasi-crystalline exclusion zone (EZ) described by Pollack as the fourth phase of water. This is retrospective analysis of experimental and clinical data using an infrared pulsed laser device (IPLD). It found photo-induced effects over the water dynamics of burned rat tissue monitored by 1 H-NMR transverse relaxation times (1/T2), indicating significantly greater structuring of water. In addition, a microdensitometry study of T2 weighted tumor heterogeneities from a phase I clinical trial of the IPLD in patients with advanced neoplasias and an algorithm for tumor characterization indicated significantly increased structuring of water, possibly proving a photobiomodulation effect over the EZ associated with histologically-confirmed selective photo-induced tumor cell death. To the best of our knowledge, this is the first clinical demonstration of light-induced effects over the EZ. It supports our premise that LPBM can increase potential energy in the EZ, which then acts as a rechargeable electrolytic bio-battery for the external selective supplementation of the energy demand required for cellular work, signaling pathways and gene expression in the presence of injury-induced redox potentials. It further suggests that EZ structuring may be used as a predicator of anticancer response before measurable tumor volume reduction.

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“…Injured corneas healed faster with infrared therapy. 12 In 2003, Janice Eells, et al, 13 found that stimulating the retina with red and near infra-red light prevented retinal damage in methyl alcohol-poisoned mice. LLLT has shown great potential in the treatment of three of the leading causes of blindness: glaucoma, macular degeneration, and cataracts.…”

mentioning

confidence: 99%

Syntonic Phototherapy

Gottlieb

Wallace²

2010

Photomedicine and Laser Surgery

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C linical and basic research in the last decades showing the impact of light on cells, tissues, blood, circadian rhythms, and mood disorders has increased the acceptance of light as a healing agent. This article describes syntonic optometric phototherapy in hopes of stimulating interest and research to validate and expand its use. We are very grateful to Dr. Raymond Lanzafame, PMLS, Editor-in-Chief, for inviting us to write this guest editorial. Syntonics uses noncoherent, nonpolarized, nonnarrowband light delivered into the eyes to treat visual dysfunctions, brain injury, headache, strabismus, eye pathology, learning disability, and mood and developmental syndromes. Syntonics is a local and nonlocal therapy that is primarily neurologic in action and neurobehavioral in effect. The eyes permit direct, noninvasive application of light to the retinal blood supply and to nonvisual, retinal photoreceptors that signal circadian and other brain centers. Patients generally look at prescribed colors for 20 minutes=day, three to five treatments per week for 20 treatments. Visual field, pupil, and binocular testing, medical history, and current symptoms determine the syntonic filter prescription. Here we describe syntonic theory, equipment, clinical procedures, and outcomes by using neurorehabilitation of brain injury to illustrate syntonic phototherapy. Syntonic optometry was conceived of in the 1920s by H. Riley Spitler, O.D., M.D. After studying the works of Pleasanton, 1 Pancoast, 2 Babbitt, 3 and Ghadiali, 4 Spitler began systematic experiments with rabbits raised in various light environments. By 1916, he began to investigate the therapeutic use of light through visual pathways via the eyes. Spitler worked with Carl Loeb, M.D., to develop Specific Light Therapy 5 and adapted this approach for optometrists by applying light directly into the eyes to treat visual problems. Spitler's central thesis, published as The Syntonic Principle, in 1941, concluded that chronic systemic, mental= emotional, and visual ailments were caused primarily by autonomic nervous and endocrine imbalance and that specific light frequencies shined into the eyes could stimulate or sedate autonomic and endocrine functioning to restore balance via direct retinal input to thalamic and hypothalamic regulatory centers, thereby correcting visual dysfunctions at their source. His model suggests that red, orange, and yellow light on the low-energy, long-wavelength side of the visible spectrum acts to stimulate the sympathetic nervous system, green (mid-spectrum) yields physiological balance, and blue and indigo (high energy, fast frequencies

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Ophthalmic effects of low-energy laser irradiation

Cited by 6 publications

References 40 publications

Photo-Infrared Pulsed Bio-Modulation (PIPBM): A Novel Mechanism for the Enhancement of Physiologically Reparative Responses

Photo-Infrared Pulsed Bio-Modulation (PIPBM): A Novel Mechanism for the Enhancement of Physiologically Reparative Responses

Water-light interaction: A novel pathway for multi hallmark therapy in cancer

Syntonic Phototherapy

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