Ophthalmic Manifestations of Leukemia

Гришина, Е. Е.; Мамонтов, А. О.

doi:10.18786/2072-0505-2016-44-5-587-591

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…As in prior research, there was a strong relationship between ocular involvement and same-session mortality rates. 24 25 In accordance with Marylin et al ., 25 the significance of ophthalmological evaluation in the systematic assessment of disease status and prognosis in patients with leukemia can be inferred.…”

Section: Discussionsupporting

confidence: 86%

Ocular Manifestations of Newly Diagnosed Acute Leukemia Patients

Mirshahi

Ghassemi

Koochakzadeh

et al. 2022

Journal of Current Ophthalmology

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Purpose: To present primary ocular manifestations in acute leukemia. Methods: This cross-sectional descriptive hospital-based study evaluated all newly diagnosed leukemia patients of three referral hospitals of Tehran University of Medical Sciences in 2015–2016 and Mahak Hospital in Tehran in 2017. Exclusion criteria included the patients with the previous history of chemotherapy, cases of relapsing disease, and the patients with a history of ocular disease or other systemic conditions with ophthalmic manifestations. Results: A total of 85 patients (170 eyes) were evaluated in our study, including 29 children (34.1%) and 43 females (50.6%). The mean patient age was 37.84 ± 11.91 years in the adult group and 6.28 ± 4.70 years in the pediatric category. Ophthalmic involvement was seen in 27 patients (31.8%), including 6 pediatric patients (20.7%) and 21 adult patients (37.5%). Two patients (2.3%) had direct infiltration by leukemic cells and 76 patients (89.41%) of patients were asymptomatic. There was a correlation between ophthalmic involvement and platelet count and hemoglobin level. In patients with ocular signs, higher mortality rates were observed. Conclusions: At the time of diagnosis in acute leukemia patients, complete ophthalmic evaluation including dilated fundus examination is suggested as ocular involvement in these patients is common and sometimes asymptomatic. Ophthalmic involvement in leukemic patients should be identified in a timely manner, particularly in individuals with low platelet counts and hemoglobin levels, due to the potential prognostic relevance.

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Section: Discussionsupporting

confidence: 86%

Ocular Manifestations of Newly Diagnosed Acute Leukemia Patients

Mirshahi

Ghassemi

Koochakzadeh

et al. 2022

Journal of Current Ophthalmology

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show abstract

“…4 The ophthalmic presentation seems to be a poor prognostic sign. 4,21,24,25 A study comparing the 5-year survival rate between patients with and without ophthalmic manifestations has concluded a significantly lower survival for the group of ocular involvement. 26 In the current study, the mortality rate did not significantly differ between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Manifestations of Newly Diagnosed Acute Leukemia Patients in a Tunisian Cohort

Sayadi¹,

Gouider²,

Allouche³

et al. 2022

OPTH

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To describe ocular manifestations of acute leukemia in a Tunisian cohort and to assess the associations between ophthalmic findings and epidemiological, clinical, and biological features of the disease. Methods: A prospective study included patients newly diagnosed with acute leukemia referred to our clinics between January 2019 and July 2020. All patients underwent a complete ophthalmic evaluation and spectral-domain optical coherence tomography (SD-OCT) at presentation, then every two months during one year. We defined two groups: Group 1 included patients with leukemic ophthalmopathy and group 2 included patients with normal ophthalmic examination. Results: Forty-six patients were enrolled. The mean age of patients was 32.1±15.3 years. The sex ratio M/F was 1.55 (28 male patients and 18 females). Twenty-nine patients (63%) had acute myeloid leukemia (AML), and 17 (37%) had acute lymphoblastic leukemia (ALL). The average follow-up was 9.1 months (range: 3-12 months). We observed ophthalmic manifestations in 28 patients (61%). Among them, 17 (61%) had vision-threatening complications. The posterior segment was the most common site of ocular involvement (82% of group1). Primary leukemic infiltration (Disc edema, ptosis, exophthalmos) was present in 13 eyes (14.1%). Twenty-seven eyes (29.3%) had secondary involvement lesions (Subconjunctival hemorrhage, periorbital ecchymosis, retinal/subhyaloid hemorrhage, dilated/tortuous veins). Twenty-one eyes (22.8%) showed other ocular manifestations which etiopathogenesis is not yet fully understood (White-centred hemorrhages, cotton-wool spots, serous retinal detachment, hemorrhagic pigment epithelial detachment). Leukemic retinopathy was significantly more frequent in adults (23/39 and 1/7 in adult and pediatric groups, respectively; p=0.003). Patients suffering from AML were more likely to have secondary ocular involvement (20/29 and 7/17 in AML and ALL patients, respectively; p=0.047). Retinal hemorrhages were statistically associated with anemia and thrombocytopenia (p=0.041 and p=0.034; respectively). Conclusion: Leukemic ophthalmopathy seems to be frequent and may lead to severe visual impairment. An ophthalmic assessment complemented with SD-OCT has paramount importance in all newly diagnosed acute leukemic patients.

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Papilledema as a sign of intracranial hypertension

Serova¹,

Eliseeva²

2022

Vestn. oftal'mol.

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Ophthalmic Manifestations of Leukemia

Cited by 7 publications

References 17 publications

Ocular Manifestations of Newly Diagnosed Acute Leukemia Patients

Ocular Manifestations of Newly Diagnosed Acute Leukemia Patients

Ophthalmic Manifestations of Newly Diagnosed Acute Leukemia Patients in a Tunisian Cohort

Papilledema as a sign of intracranial hypertension

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