Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review

Georgalas, Ilias; Paraskevopoulos, Theodore; Koutsandrea, Chryssanthi; Kardara, Evgenia; Malamos, Panagiotis; Ladas, Dimitrios S; Papaconstantinou, Dimitris

doi:10.1155/2015/574086

Cited by 39 publications

(36 citation statements)

References 74 publications

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“…Choroidal metastases are associated with a disproportionately large amount of subretinal fluid compared with primary choroidal melanomas. [1,3,5] Both of our patients had retinal detachment at presentation, which is not uncommon in women with metastatic breast cancer. In contrast, with melanomas, the deposit is usually of a significant size before an exudative retinal detachment can be seen.…”

Section: Discussionmentioning

confidence: 63%

Ocular metastasis as initial presentation in breast cancer

et al. 2017

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Two patients presented to their ophthalmologists with vision disturbances. On ocular examination, retinopathic lesions were observed. On subsequent examination, these lesions were diagnosed as metastases of breast cancer. Neither patient had a history of breast cancer. In patients with breast cancer and multiple metastases, ocular metastases are well described. However, the latter is uncommon as a presenting complaint. Med J 2017;107(8):694-696. DOI:10.7196/SAMJ.2017.v107i8.12352 S Afr

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Section: Discussionmentioning

confidence: 63%

Ocular metastasis as initial presentation in breast cancer

et al. 2017

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“…They are identified pathologically as solid deposits of the muscles. Orbital metastasis may cause exophthalmos, from mass effect, or enophthalmos [ 7 ]. Metastatic breast cancer rarely can manifest as cranial nerve palsies (incidence of 0.13%).…”

Section: Discussionmentioning

confidence: 99%

Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis

Tabai

Hazboun

Sakuma

et al. 2016

Case Reports in Otolaryngology

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Introduction. A range of traumatic, vascular, inflammatory, infectious, and neoplastic processes can affect the orbit and its structures. In the area of otolaryngology, the rhino-orbital-cerebral involvement of invasive fungal rhinosinusitis can affect the orbit, which may look like initially a rhinosinusitis or even mimic malignancy. Case Presentation. Female patient, 32 years old, with headache and ocular proptosis. She was using prednisone in immunosuppressive doses for a year and had breast cancer treated three years earlier. The initial CT scan showed opacification of the sphenoid and ethmoid sinuses, left intraorbital involvement and contrast impregnation in the cavernous sinus. The biopsy resulted positive for invasive ductal carcinoma of the breast. Discussion. The initial CT scan of our patient showed both signs of early changes of invasive fungal rhinosinusitis (IFR) and possible metastatic involvement. The intracranial extension and ocular involvement are usually the most common signs of IFR (first hypothesis). Among metastases at the orbit and the eye, breast and lung carcinomas are the most frequent. Conclusion. Although several studies on the differential diagnosis of orbital lesions exist, especially when it concerns the involvement of the nasal cavity, the diagnosis by imaging is still a challenge.

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“…1,2 Lokasi paling sering terjadinya metastasis pada kanker payudara yaitu paru dan pleura (15-20%), tulang (20-60%), hati (5-15%), otak ( 5-10%) dan metastasis lokal/regional (20-40%%). 3 Selain lima lokasi yang disebutkan sebelumnya, kanker payudara juga dapat bermetastasis ke orbita. Angka kejadian metastasis orbita 2-9% dari semua kasus keganasan pada dewasa dan 8-10% berasal dari kanker payudara.…”

Section: Pendahuluanunclassified

“…Mean survival time pasien dengan kanker payudara adalah sekitar 22-31 bulan setelah metastasis ke orbita. 3,4 Terapi pada pasien dengan kanker payudara…”

Section: Pendahuluanunclassified

Invasive Carcinoma Mammae dengan Metastasis Orbita, Tulang, dan Paru

Avryna

Wahid²,

Fauzar³

2019

JKA

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AbstrakCarcinoma mammae (kanker payudara) merupakan penyakit keganasan yang paling banyak terjadi pada wanita di negara berkembang dan merupakan penyebab kematian wanita kedua di Amerika Serikat. Pada tahun 2014 terdapat 232.000 kasus baru pada wanita di Amerika Serikat dan dengan angka kematian 40.000 jiwa. Invasive breast carcinoma paling banyak berasal dari epitel duktus dan lebih dari 75% merupakan invasive ductal carcinoma not otherwise specified (IDC-NOS). Angka kejadian metastasis orbita 2-9% dari semua kasus keganasan pada dewasa dan 8-10% berasal dari kanker payudara. Pada kasus ini, wanita 36 tahun datang dengan keluhan sesak napas dan terdapat benjolan pada mata kiri sejak 2 bulan yang lalu. Pasien telah dikenal menderita Ca Mammae dengan hasil biopsy jaringan ditemukan Invasive Carcinoma Mammae Of No Special Type (NST) Grade II sejak 1,5 tahun sebelumnya, namun menolak pengobatan dan kemoterapi. Saat ini telah terjadi metastasis di orbita, metastasis tulang dan paru. Pasien diberikan kemoterapi dengan regimen Carboplatin (AUC 6) dan Paclitaxel 170 mg/m 2 dan mengalami perbaikan secara signifikan.Kata Kunci: kanker payudara, metastasis multipel, metastasis orbita, metastasis tulang, metastasis paru Abstract Carcinoma mammae is the most common malignancy in women in developing countries and is the second leading cause of death of women in the United States. In 2014, there were 232,000 new cases of women in the United States and with a death toll of 40,000. Invasive breast carcinoma is mostly from ductal epithelium and more than 75% is invasive ductal carcinoma not otherwise specified (IDC-NOS). The incidence of orbital metastases is 2-9% of all malignant cases in adults and 8-10% are from breast cancer. In this case, a 36-year-old woman came with a complaint of shortness of breath and a lump in the left eye since 2 months ago. The patient has been known to suffer from Mammary Ca with tissue biopsy results found in invasive carcinoma mammary of no special type (NST) Grade II since 1.5 years before, but refused treatment and chemotherapy. At present there has been metastasis in the orbit, bone and lung metastases. Patients were given chemotherapy with the regimen of Carboplatin (AUC 6) and Paclitaxel 175 mg/m 2 and experienced significant improvement.

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Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review

Cited by 39 publications

References 74 publications

Ocular metastasis as initial presentation in breast cancer

Ocular metastasis as initial presentation in breast cancer

Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis

Invasive Carcinoma Mammae dengan Metastasis Orbita, Tulang, dan Paru

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