Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the safety and the efficacy of product “BIO-COX 120G” as feed additive in accordance with Council Directive 70/524/EEC

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doi:10.2903/j.efsa.2004.75

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Organic acids, plant extracts, prebiotics, and enzyme preparation have been used as alternative to antibiotics as feed additives for livestock production (36,37). In swine production, MCE or benzoic acid supplementation are effective in promoting growth performance, feed efficiency and preventing the occurrence of diarrhea at the weaning stage (15,38). Previous studies found that MCE benefitted the growth performance of broilers (12,39).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Combined Supplementation of Macleaya cordata Extract and Benzoic Acid on the Growth Performance, Immune Responses, Antioxidant Capacity, Intestinal Morphology, and Microbial Composition in Weaned Piglets

et al. 2021

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Because the use of antibiotics is forbidden, piglets experience a considerable weanling stress, resulting in increased incidence of diarrhea and death. Macleaya cordata extract or benzoic acid have anti-inflammatory, antioxidant, and antimicrobial activities that makes them potential antibiotic alternatives. The objective of this study was to evaluate the potential effects of feed supplemented with Macleaya cordata extract and benzoic acid on growth performance, immunity, antioxidant capacity, intestinal morphology, and microflora in weaned piglets. Twenty-four weaned piglets [Duroc × (Large White × Landrace)] 28 days of age and weighing 8.41 ± 0.13 kg were randomly divided in equal numbers (n = 8) into three groups fed a basal diet (CON), CON + 20 mg/kg flavomycin + 50 mg/kg quinocetone (AGP), or CON + 50 mg/kg Macleaya cordata extract + 1,000 mg/kg benzoic acid (MB). Compared with the CON diet, dietary MB or AGP increased the final weight and average daily gain, and reduced feed efficiency and the diarrhea rate (P < 0.05). Compared with the CON diet, MB supplementation increased serum superoxide dismutase (SOD activity) and decreased malondialdehyde (MDA) content (P < 0.05). Serum interleukin (IL)-10 IgA and IgM were higher (P < 0.05) in MB-fed piglets than in CON-fed piglets. Piglets fed the MB diet had greater villus height and villus height to crypt depth ratio (VC) in the duodenum, villus height in the ileum, and lower crypt depth in the jejunum than did piglets given the CON diet (P < 0.5). Piglets in the MB group had increased concentrations of acetate, propionate, butyrate, and total short-chain fatty acids in the ileum or cecum compared with the CON and AGP groups (P < 0.05). Streptococcus proportion was lower in the MB than in the AGP group. Dietary MB increased the Lactobacillus and decreased Escherichia-Shigella populations compared with the CON group (P < 0.05). The study results indicate that MB can be used to replace AGP as a feed supplement for weaned piglets.

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Section: Discussionmentioning

confidence: 99%

“…Benzoic acid is the simplest aromatic carboxylic acid. It was approved at a dose of 0.5-1.0% in swine rearing by the European Union (15). The small intestine is the main site of benzoic acid absorption and transport by the monocarboxylic acid transporters (16).…”

Section: Introductionmentioning

confidence: 99%

Effects of Combined Supplementation of Macleaya cordata Extract and Benzoic Acid on the Growth Performance, Immune Responses, Antioxidant Capacity, Intestinal Morphology, and Microbial Composition in Weaned Piglets

et al. 2021

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Long-term broiler litter amendments can alter the soil’s capacity to sorb monensin

Doydora

Sun

Cabrera

et al. 2017

Environ Sci Pollut Res

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Monensin is a common antiparasitic drug given to poultry that contaminates poultry manure and bedding material (broiler litter). As broiler litter is commonly applied to agricultural fields as fertilizer, monensin could be released beyond the farm if it is not retained or degraded in the soil. This study aimed to assess the impact of long-term surface application of broiler litter (i.e., 17 years) on the capacity of pasture soil to sorb monensin. The soils were exposed to a range of monensin concentrations (0.18 to 1.81 μmol L), solution pH (pH 4-9), and temperatures (15, 25, and 35 °C) and monensin was measured as loss from solution (i.e., sorption). Soils receiving long-term litter applications were hypothesized to retain more monensin than unamended soils because they have higher organic matter concentrations. However, soils from broiler litter-amended fields sorbed 46% less monensin than soils from unamended fields, likely because broiler litter also increased soil pH. The sorption of monensin to soil was strongly influenced by pH, with an order of magnitude greater sorption at pH 4 than at pH 9. Both soils had similar capacity to sorb monensin under similar solution pH, despite differences in organic carbon content (with the broiler litter-amended having 25% greater relative to the unamended soil). Temperature did not significantly impact monensin sorption for either soil. Our findings suggest increasing soil pH, for instance through liming, could enhance mobility of monensin.

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Fate and transport of atrazine in a sandy soil in the presence of antibiotics in poultry manures

Kim

Fan

Prasher

et al. 2011

Agricultural Water Management

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Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the safety and the efficacy of product “BIO-COX 120G” as feed additive in accordance with Council Directive 70/524/EEC

Cited by 6 publications

References 31 publications

Effects of Combined Supplementation of Macleaya cordata Extract and Benzoic Acid on the Growth Performance, Immune Responses, Antioxidant Capacity, Intestinal Morphology, and Microbial Composition in Weaned Piglets

Effects of Combined Supplementation of Macleaya cordata Extract and Benzoic Acid on the Growth Performance, Immune Responses, Antioxidant Capacity, Intestinal Morphology, and Microbial Composition in Weaned Piglets

Long-term broiler litter amendments can alter the soil’s capacity to sorb monensin

Fate and transport of atrazine in a sandy soil in the presence of antibiotics in poultry manures

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