Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium Sulphate as a mineral substance in foods intended for the general population

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doi:10.2903/j.efsa.2004.112

Cited by 2 publications

(2 citation statements)

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“…Both committees established a group acceptable daily intake (ADI) . Calcium sulphate was evaluated by EFSA in 2003, 2004 and 2008 for use in foods for particular nutritional uses (37), as a mineral substance in foods intended for the general population (38) and for use as a source of calcium in food supplements (39). The overall conclusion in the evaluations was that calcium sulphate as a source of calcium or as a mineral substance in foods is of no safety concern (37)(38)(39).…”

Section: Introductionmentioning

confidence: 99%

“…Calcium sulphate was evaluated by EFSA in 2003, 2004 and 2008 for use in foods for particular nutritional uses (37), as a mineral substance in foods intended for the general population (38) and for use as a source of calcium in food supplements (39). The overall conclusion in the evaluations was that calcium sulphate as a source of calcium or as a mineral substance in foods is of no safety concern (37)(38)(39). Functional uses of calcium sulphate also include, Yeast food, dough conditioner, firming agent, sequestrant, anhydrous Chemical formula CaSO4 dihydrate: CaSO4•2H2O calcium sulphate is permitted as a source of calcium in food supplements, in foods in general and in foods for special nutritional purposes , the majority of sulphate intake from the diet comes from protein-derived methionine and cysteine (40).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Potassium Bromate, Calcium Sulfate and Synergistic Toxic Effects in Male Mice

Imarah

Najm

2023

Bio. Jour.

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Food additives are the basis of the modern food industry, and play an important role in improving the color, smell, and taste of food, altering its nutritional structure, perfecting its processing conditions, and extending its shelf life. Twenty four adult male Swiss albino mice were used in our experiment : Group (1) mice were Intraperitoneally injected of normal saline 0.5 ml (as control). Group (2) mice were intraperitoneally injected of well dispersed Potassium Bromate 320 mg/kg of body weight for two months (twice weekly). Group (3) mice were faded Calcium sulfate as chew of food 0.03% w/w for two months (daily intake). Group (4) mice were intraperitoneally injected of well dispersed Potassium Bromate 320 mg/kg of body weight for two months (twice weekly) and also given Calcium sulfate as chew of food 0.03% W/W for two months (daily intake). After the end of project protocol the mice had been sacrificed and blood collocated and this parameters was evaluated white blood cells (WBC) , red blood cells (RBC) ,platelet (PLT),hematocrit (HCT), and hemoglobin concentration (Hgb). The result showed there is highly significant decrease for WBC for the (group 2 and group 4) , Red blood cell count show that there is highly significant decrease of (group 2 and4), In contrast the result for Hemoglobin concentration show there were highly significant increase in group 2 and 4 by comparing with control group , also highly significant increase for Hct percentage for the (group 2 and 4) by comparing with control group and group 3. Finally platelets count result show that there is highly significant decrease in group 2 and group 4. From current study We can conclude that there are different harmfully effects of KBrO3 and the synergistic effect with CaSo4 on the animal model and according to that on human due to the daily uptake of this compounds in our life style ,according to the hematological indices (WBC),(RBC), (Hgb), (Hct), and finally (PLT). Thus the using of KBrO3 and CaSo4 should be limited and used specific documented concentration to reduce its unfavorable effects

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Potassium Bromate, Calcium Sulfate and Synergistic Toxic Effects in Male Mice

Imarah

Najm

2023

Bio. Jour.

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Re‐evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive

Flavourings¹,

Younes²,

Aquilina³

et al. 2019

EFS2

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The Panel on Food Additives and Flavourings (FAF) provided a scientific opinion re-evaluating the safety of sulphuric acid (E 513) and its sodium (E 514), potassium (E 515), calcium (E 516) and ammonium (E 517) salts when used as a food additive. The Panel considered that adequate exposure and toxicity data were available. Sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, E 514, E 515, E 516, E 517) are authorised food additives in the EU, in accordance with Annex II and Annex III to Regulation (EC) No 1333/2008. In the refined estimated exposure non brand-loyal scenario, mean exposure ranged from 0.4 mg sulphate/kg body weight (bw) per day in infants to 35 mg sulphate/kg bw per day in toddlers. The high percentile of exposure ranged from 3 mg sulphate/kg bw per day in adolescents to 68 mg sulphate/kg bw per day in toddlers. The Panel considered sulphates of low acute toxicity and there is no concern with respect to genotoxicity and carcinogenicity. The Panel noted that the exposure to sulphates at mean and 95th percentile in the non brand-loyal scenario as well as in the other scenarios, is far below the 300 mg/kg a dose that induced laxative effect in humans. Based on the toxicological database available, the Panel concluded that the exposure to sulphuric acid (E 513), sodium sulphate (E 514), potassium sulphates (E 515), calcium sulphate (E 516) and ammonium sulphate (E 517) does not raise a safety concern at the reported uses and use levels and there is no need for a numerical acceptable daily intake (ADI).

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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium Sulphate as a mineral substance in foods intended for the general population

Cited by 2 publications

References 4 publications

Assessment of Potassium Bromate, Calcium Sulfate and Synergistic Toxic Effects in Male Mice

Assessment of Potassium Bromate, Calcium Sulfate and Synergistic Toxic Effects in Male Mice

Re‐evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive

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