Opioid-dependent regulation of high and low fear responses in two inbred mouse strains

Szklarczyk, Klaudia; Korostyński, Michał; Cieślak, Przemysław Eligiusz; Wawrzczak-Bargieła, Agnieszka; Przewłocki, Ryszard

doi:10.1016/j.bbr.2015.06.001

Cited by 16 publications

(4 citation statements)

References 54 publications

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“…Thus, as discussed by Browne and Lucki [ 200 ], pharmacological blockade of MORs enhances the acquisition of conditioned fear and increases freezing in response to a conditioned stimulus, while KOR antagonism shows opposite effects [ 233 ]. In agreement, morphine treatment attenuates the acquisition of fear memories both in rats [ 234 ], mice [ 235 ], and humans [ 236 ]. Moreover, this effect seems to be mediated by specific brain areas such as the amygdala and the periaqueductal gray [ 237 ].…”

Section: Receptor-receptor Interactions With Relevance For Anxietymentioning

confidence: 80%

Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

Mora

Borroto‐Escuela

Crespo-Ramírez

et al. 2022

Cells

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Among mental diseases, major depressive disorder (MDD) and anxiety deserve a special place due to their high prevalence and their negative impact both on society and patients suffering from these disorders. Consequently, the development of novel strategies designed to treat them quickly and efficiently, without or at least having limited side effects, is considered a highly important goal. Growing evidence indicates that emerging properties are developed on recognition, trafficking, and signaling of G-protein coupled receptors (GPCRs) upon their heteromerization with other types of GPCRs, receptor tyrosine kinases, and ionotropic receptors such as N-methyl-D-aspartate (NMDA) receptors. Therefore, to develop new treatments for MDD and anxiety, it will be important to identify the most vulnerable heteroreceptor complexes involved in MDD and anxiety. This review focuses on how GPCRs, especially serotonin, dopamine, galanin, and opioid heteroreceptor complexes, modulate synaptic and volume transmission in the limbic networks of the brain. We attempt to provide information showing how these emerging concepts can contribute to finding new ways to treat both MDD and anxiety disorders.

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Section: Receptor-receptor Interactions With Relevance For Anxietymentioning

confidence: 80%

Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

Mora

Borroto‐Escuela

Crespo-Ramírez

et al. 2022

Cells

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“…In support, studies examining LP/J, SM/J, & 129S1 inbred mice have found high levels of learning in hippocampus-dependent tasks ( 56 ) including contextual fear conditioning ( 57 , 58 ) relative to other tested strains. Similarly, FVB/NJ, SWR/J, and BTBRT+ strains exhibit low levels of hippocampus-dependent learning ( 35 , 59 – 61 ). It should be noted that FVB/NJ and SWR/J strains possess a Pde6b gene mutation that leads to compromised visual acuity ( 62 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains

et al. 2021

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Learning is a critical behavioral process that is influenced by many neurobiological systems. We and others have reported that acetylcholinergic signaling plays a vital role in learning capabilities, and it is especially important for contextual fear learning. Since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (AChE), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. We measured conditioned fear behavior and AChE activity in the dorsal hippocampus, ventral hippocampus, and cerebellum. Acetylcholinesterase activity varied among inbred mouse strains in all three brain regions, and there were significant inter-strain differences in contextual and cued fear conditioning. There was an inverse correlation between fear conditioning outcomes and AChE levels in the dorsal hippocampus. In contrast, the ventral hippocampus and cerebellum AChE levels were not correlated with fear conditioning outcomes. These findings strengthen the link between acetylcholine activity in the dorsal hippocampus and learning, and they also support the premise that the dorsal hippocampus and ventral hippocampus are functionally discrete.

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“…In the same study, administration of MOPr antagonist (naltrexone) or DOPr antagonist (naltrindole) increased fear response in SWR/J mice, which could be restored with a DOPr agonist. These results suggest that resistance in the face of traumatic experiences inducing fear involves ENK from the AMG and that vulnerability can be modulated by administration of OPr agonists [44]. Finally, it has been shown by Poulin et al that the downregulation of ENK in the rat CEA decreases unconditioned fear [15].…”

Section: Enkephalins and Their Opioid Receptorsmentioning

confidence: 96%

“…An increased expression of ENK mRNA levels is similarly observed after repeated footshocks, in the AMG of SWR/J mice, an inbred strain showing a reduced fear response, while this expression was unchanged in C57Bl/6J mice, an inbred strain showing a high fear response [44]. In the same study, administration of MOPr antagonist (naltrexone) or DOPr antagonist (naltrindole) increased fear response in SWR/J mice, which could be restored with a DOPr agonist.…”

Section: Enkephalins and Their Opioid Receptorsmentioning

confidence: 99%

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

et al. 2017

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Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer's disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity. How can we promote or improve resilience to chronic stress? Numerous studies have proposed mechanisms that could trigger this desirable process. The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. However, their role in the resilience to chronic stress has received much less attention. This review presents the evidence for an emerging involvement of enkephalin signaling through its two associated opioid receptors, μ opioid peptide receptor and δ opioid peptide receptor, in the natural adaptation to stressful lifestyles.

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Opioid-dependent regulation of high and low fear responses in two inbred mouse strains

Cited by 16 publications

References 54 publications

Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

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