“…While the condition itself is still poorly understood, the seriousness of a hyperalgesic state for postoperative patients has provided the motivation for the fast growing practice of opioid-free anaesthesia (OFA) in human medicine. Additional reported benefits of OFA include reduced post-operative opioid requirements (Feld et al, 2003;Mansour et al, 2013;Bakan et al, 2015), reduced incidence of post-operative nausea and vomiting (Mather and Peutrell, 1995;Callesen et al, 1999;Ziemann-Gimmel et al, 2014;Bakan et al, 2015), reduced intraoperative hypotension (Jagannathan et al, 2007;Bakan et al, 2015), and reduced post-operative sedation levels (Feld et al, 2003). Opioids provide the mainstay of analgesia in a significant proportion of veterinary anaesthesia.…”