Opioid-induced bowel dysfunction

Chang, Howard Y.; Lembo, Anthony

doi:10.1007/s11938-008-0002-1

Cited by 8 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the results of a long-term safety study found that alvimopan was associated with an increased risk of cardiovascular events compared with placebo. These findings have been investigated to determine their clinical relevance and the potential consequences for the safety of alvimopan, especially for long-term use [84,85] . Alvimopan is registered in the USA for treatment of postoperative ileus, but is contraindicated in patients using opioids for more than 7 days.…”

Section: Other Potential Strategiesmentioning

confidence: 99%

Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach

et al. 2008

View full text Add to dashboard Cite

Opioid analgesics are the cornerstone of pain management for moderate-to-severe cancer pain and, increasingly, chronic noncancer pain. Despite proven analgesic efficacy, the use of opioids is commonly associated with frequently dose-limiting constipation that seriously impacts on patients’ quality of life. Agents currently used to manage opioid-induced constipation (OIC), such as laxatives, do not address the underlying opioid receptor-mediated cause of constipation and are often ineffective. A significant need therefore exists for more effective treatment options. A novel approach for selectively and locally antagonizing the gastrointestinal effects of opioids involves the coadministration of a μ-opioid receptor antagonist with negligible systemic availability, such as oral naloxone. Combination therapy with prolonged-release (PR) oxycodone plus PR naloxone has been shown to provide effective analgesia while preventing or reducing constipation. The current article highlights this novel strategy in its potential to significantly improve the quality of life of patients suffering from chronic pain, affording patients the benefit of full analgesia, without the burden of OIC.

show abstract

Section: Other Potential Strategiesmentioning

confidence: 99%

Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Gender ( p = 0.009), opioid use ( p = 0.034), BPI severity score ( p = 0.021), and BPI interference score ( p < 0.001) are significantly associated with OIC. Taking into account the available literature [ 28 , 40 , 41 ], we decided to include depressive disorders diagnosis in our multivariate regression analysis model.…”

Section: Resultsmentioning

confidence: 99%

“…Morphine seems to be the opioid with the highest associated risk of OIC, while transdermal preparations of Buprenorphine and Fentanyl are associated with lower risk [ 25 ]. However, the prevalence may also vary due to differences in clinical supervision on OIC development and prophylactic laxative therapy prescription, as well as variability in patient's perception of their constipation symptoms [ 19 , 26 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study

Veiga

Mendonça²,

Sampaio

et al. 2018

Pain Research and Treatment

View full text Add to dashboard Cite

Background High rates of opioid use for chronic noncancer pain (CNCP) have been reported worldwide, despite its association with adverse events, inappropriate use, and limited analgesic effect. Opioid-induced constipation (OIC) is the most prevalent and disabling adverse effect associated with opioid therapy. Our aim was to assess the incidence, health related quality of life (HRQOL), and disability in OIC patients. Methods A prospective cohort study was performed, with 6 months of follow-up, of adult CNCP patients consecutively admitted in 4 multidisciplinary pain clinics (MPC). Demographic and clinical data have been collected. Brief Pain Inventory (BPI) and Short version of Treatment Outcomes in Pain Survey (S-TOPS) were used to measure functional outcomes and HRQOL. OIC was assessed using Bowel Function Index (BFI). Results 694 patients were recruited. OIC prevalence at baseline was 25.8%. At 6 months, OIC incidence was 24.8%. Female gender (OR = 1.65, p = 0.039), opioid therapy (OR 1.65, p = 0.026), and interference pain score on BPI (OR 1.10, p = 0.009) were identified as OIC independent predictors. OIC patients presented higher disability and pain interference and severity scores. OIC patients reported less satisfaction with outcome (p = 0.038). Discussion Constipation is a common adverse event among opioid users with major functional and quality of life impairment. These findings emphasise the need of OIC adequate assessment and management.

show abstract

“…Patients receiving opioid medication for postoperative or chronic pain often have opioid-induced bowel dysfunction (OBD). The most common symptoms of OBD are intestinal motility disorder and constipation ( 37 - 41 ). 4) Abdominal muscles contraction is one of the factors in defecation.…”

Section: Resultsmentioning

confidence: 99%

Avicenna’s View on the Etiologies of Intestinal Obstruction

Moradi

Balti

Minaiee

et al. 2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

Context:Bowel obstruction is one of the most common causes of acute abdomen. Because of heterogeneity of patients’ population and variety of causes, therapeutic strategies are not standardized, so treatment of intestinal obstruction is a surgical challenge in many cases. A traditional medicine approach could help detect some issues that were ignored by modern medicine. One of the major schools of medicine, with a history of several thousand years, is Iranian traditional medicine. In this regard, Avicenna, who lived in the medieval period, has had a great influence on the medical knowledge of the world by writing an encyclopedia of medicine entitled “Qanun of Medicine.”Evidence Acquisition:The aim of this study was to investigate Avicenna’s views on the causes of intestinal obstruction and comparing them to modern medicine views. This is a review study on an Iranian traditional textbook of medicine by Avicenna, entitled “Qanun of Medicine” (in short “Qanun”). We used Qanun in its original language (Arabic) along with its Persian translation. It consists of 5 books. Part 16 of the third book talks about intestinal anatomy and introduces some intestinal diseases such as “qoolinj” and “ilavos.” Intestinal obstruction can be a kind of “qoolinj” or “ilavos” disease. All intestinal obstruction etiologies in Qanun are searched in international and Iranian databases (Scopus, ISI, SID, and Iranmedex) and similar causes in modern medicine will be discussed in this article.Results:According to Qanun, 16 causes are involved in intestinal etiologies of bowel obstruction such as “reeh,” mucoid phlegm, abdominal hot and dry distemperament, decreased bile secretion, job, and so on while modern medicine considers some of them, for instance, volvulus, intestinal herniation, worm, intestinal pseudo-obstruction, and opiate.Conclusions:Attention to the similar causes of intestinal obstruction in modern medicine and traditional medicine is the starting point for investigation of noninvasive diagnostic and therapeutic methods that have been mentioned in Qanun. In addition, etiologies which are missed in modern medicine can open new doors to the researchers and gastroenterologists for the study, diagnosis, and prevention of the disease.

show abstract

Opioid-induced bowel dysfunction

Cited by 8 publications

References 36 publications

Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach

Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach

Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study

Avicenna’s View on the Etiologies of Intestinal Obstruction

Contact Info

Product

Resources

About