Opioid peptide levels in the brain and blood of rats with immobilization stress

Neurotransmitters and neuropeptides interact in several ways. We studied a new type of interaction: the effect of neurotransmitters on the saturable system that transports Tyr-MIF-1 and the enkephalins out of the central nervous system (CNS). The neurotransmitters were introduced into the lateral ventricle of the brain with radioiodinated peptide, using an established method previously shown to accurately quantify the amount of peptide being transported from the CNS to the blood. Serotonin inhibited transport, histamine stimulated transport, and dopamine, acetylcholine, epinephrine, GABA, kainic acid, cAMP and cGMP were without effect. Cyproheptadine, a serotonin antagonist, stimulated transport. Of several psychotropic agents tested, only tranylcypromine had a statistically significant effect and stimulated transport. Of the serotonin receptor specific agents tested, those with 5HT1 activity most consistently affected transport. We conclude that serotonin, and perhaps histamine, are important modulators of the system that transports Tyr-MIF-1 and the enkephalins out of the CNS.

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Cold-restraint stress reduces [3H]etorphine binding to rat brain membranes: Influence of acute and chronic morphine and naloxone

Hnatowich

Labella

Kiernan

et al. 1986

Brain Research

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Opioid peptide levels in the brain and blood of rats with immobilization stress

Cited by 11 publications

References 10 publications

Biochemical Indices of Stress Associated with Short-Term Restraint in Hormel and Yucatan Miniature Swine

Biochemical Indices of Stress Associated with Short-Term Restraint in Hormel and Yucatan Miniature Swine

Effect of neurotransmitters on the system that transports Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin

Cold-restraint stress reduces [3H]etorphine binding to rat brain membranes: Influence of acute and chronic morphine and naloxone

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