Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus

Javid, Farideh A.; Naylor, R.J.

doi:10.1016/s0091-3057(01)00470-1

Cited by 15 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although not tested here, musk shrews are reported to display more complicated responses to morphine. Although morphine alone appears not to produce emesis in musk shrews [25], naloxone pre-treatment can reveal morphine-induced emesis [26]. Opioid receptor agonists are well known to suppress emesis [27], usually at higher doses, and this inhibitory system is apparent in musk shrews [25, 26, 28].…”

Section: Discussionmentioning

confidence: 99%

Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews

Horn

Meyers

Pak

et al. 2012

Physiology & Behavior

View full text Add to dashboard Cite

Although partially controlled with antiemetic drugs, postoperative nausea and vomiting (PONV) continues to be a problem for many patients. Clinical research suggests that opioid analgesics and volatile anesthetics are the main triggers of PONV. The aim of this study was to develop an animal model for post-anesthesia vomiting for future studies to further determine mechanisms and preclinical drug efficacy. Ferrets (N=34) were initially used because they have served as a gold standard for emesis research. Ferrets were tested with several doses of morphine, inhaled isoflurane, and a positive control injection of cisplatin (a chemotherapy agent) to induce emesis. Musk shrews (a small animal model; N=36) were also tested for emesis with isoflurane exposure. A control injection of cisplatin produced emesis in ferrets (ip, 129.8±22.0 retches; 13.7±2.3 vomits; mean ± SEM). Morphine produced a dose-response on emesis in ferrets, with maximal responses at 0.9 mg/kg (sc, 29.6±12.6 retches; 1.8±0.9, vomits). Isoflurane exposure (2–4% for 10 min to 6 h exposure) failed to induce vomiting, was not associated with an increased frequency in emesis when combined with a low dose of morphine (0.1 mg/kg, sc), and failed to produced consistent effects on food and water intake. In contrast to ferrets, musk shrews were very sensitive to isoflurane-induced emesis (0.5 to 3%, 10 min exposure; up to 11.8±2.4 emetic episodes). Overall, these results indicate that ferrets will not be useful for delineating mechanisms responsible for isoflurane-induced emesis; however, musk shrews may prove to be a model for vomiting after inhalation of volatile agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews

Horn

Meyers

Pak

et al. 2012

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…Although morphine alone does not to produce emesis in musk shrews (Selve et al, 1994), naloxone pre-treatment can reveal morphine-induced emesis (Javid and Naylor, 2001). Opioid receptor agonists are also well known to suppress emesis (Sanger and Andrews, 2006), usually at higher doses, and this inhibitory system is apparent in musk shrews (Javid and Naylor, 2001; Kakimoto et al, 1997; Selve et al, 1994). It is unclear whether a single animal model can be used to conduct mechanistic studies on the various aspects (i.e., summation or synergistic effects) of PONV that involve inhalational anesthesia and opioid components (Fig.…”

Section: Future Directionsmentioning

confidence: 99%

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

Horn¹,

Wallisch²,

Homanics³

et al. 2014

European Journal of Pharmacology

203

130

View full text Add to dashboard Cite

Clinical research shows that postoperative nausea and vomiting (PONV) is caused primarily by the use of inhalational anesthesia and opioid analgesics. PONV is also increased by several risk predictors, including a young age, female sex, lack of smoking, and a history of motion sickness. Genetic studies are beginning to shed light on the variability in patient experiences of PONV by assessing polymorphisms of gene targets known to play roles in emesis (serotonin type 3, 5-HT3; opioid; muscarinic; and dopamine type 2, D2, receptors) and the metabolism of antiemetic drugs (e.g., ondansetron). Significant numbers of clinical trials have produced valuable information on pharmacological targets important for controlling PONV (e.g., 5-HT3 and D2), leading to the current multi-modal approach to inhibit multiple sites in this complex neural system. Despite these significant advances, there is still a lack of fundamental knowledge of the mechanisms that drive the hindbrain central pattern generator (emesis) and forebrain pathways (nausea) that produce PONV, particularly the responses to inhalational anesthesia. This gap in knowledge has limited the development of novel effective therapies of PONV. The current review presents the state of knowledge on the biological mechanisms responsible for PONV, summarizing both preclinical and clinical evidence. Finally, potential ways to advance the research of PONV and more recent developments on the study of postdischarge nausea and vomiting (PDNV) are discussed.

show abstract

“…Thus, in this study we used suncus, a motilin and ghrelin-producing mammal, to study the physiological roles of motilin. While suncus was initially established as an animal model for emesis and vomiting research [27], we found that it not only produced motilin, but also expressed the motilin receptor [28]. In addition, the general appearance of the gastric mucosa and gastrointestinal motility, including motilin-induced gastric contractions during MMC in these animals appeared to be similar to those of humans and dogs [10,20,21].…”

Section: Discussionmentioning

confidence: 68%

Motilin stimulates pepsinogen secretion in Suncus murinus

Goswami

Tanaka

Jogahara

et al. 2015

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus

Cited by 15 publications

References 29 publications

Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews

Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

Motilin stimulates pepsinogen secretion in Suncus murinus

Contact Info

Product

Resources

About