Opioids and the Neuroendocrine Control of Reproduction

Almeida, Osborne F. X.

doi:10.1007/978-3-642-77540-6_20

Cited by 5 publications

(1 citation statement)

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“…Indeed, socially induced inhibition of GnRH or LH through increased endogenous opioid peptide activity is a potential neuroendocrine pathway by which infertility through anovulation could be engineered. Endogenous opioid peptides have been found to negatively affect the secretion of gonadotrophin (Almeida 1993). The hypothalamus and pituitary are the two most important sites where opioid peptides may exert their actions upon GnRH and LH secretion.…”

Section: Measurements Of Total Pituitary Lh Revealed That the Luteotrmentioning

confidence: 99%

Teasing apart socially‐induced infertility in non‐reproductive female Damaraland mole‐rats, Fukomys damarensis (Rodentia: Bathyergidae)

Bennett

2011

Integrative Zoology

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The Damaraland mole-rat is a subterranean mammal exhibiting extreme reproductive skew with a single reproductive female in each colony responsible for procreation. Non-reproductive female colony members are physiologically suppressed while in the colony exhibiting reduced concentrations of plasma luteinizing hormone (LH) and a decreased response of the pituitary, as measured by the release of bioactive LH, to an exogenous dose of gonadotrophin releasing hormone (GnRH). Removal of the reproductive female from the colony results in an elevation of LH and an enhanced response of the pituitary to a GnRH challenge in non-reproductive females comparable to reproductive females, implying control of reproduction in these individuals by the reproductive female. The Damaraland mole-rat is an ideal model for investigating the physiological and behavioural mechanisms that regulate the hypothalamopituitary-gonadal axis. In contrast, we know less about the control of reproduction at the level of the hypothalamus. The immunohistochemistry of the GnRH system of both reproductive and non-reproductive female Damaraland mole-rats has revealed no significant differences with respect to morphology, distribution or numbers of immunoreactive GnRH perikarya. We

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Section: Measurements Of Total Pituitary Lh Revealed That the Luteotrmentioning

confidence: 99%