Opisthorchis felineus infection prevalence in Western Siberia: A review of Russian literature

Федорова, О. С.; Федотова, М М; Sokolova, Tatiana S.; Golovach, Ekaterina A.; Kovshirina, Yulia V.; Ageeva, Tatiana S.; Kovshirina, Anna E.; Kobyakova, О. S.; Огородова, Л. М.; Odermatt, Peter

doi:10.1016/j.actatropica.2017.11.018

Cited by 29 publications

(17 citation statements)

References 21 publications

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“…As the population is continuously exposed to new infections, the infection accumulates over time, resulting in high infection prevalence and intensities in older age groups. We have observed this previously for O. felineus [10]. This observation is also common in rural settings in Southeast Asia where O. viverrini is endemic [32,33].…”

Section: Prevalence Of Opisthorchis Felineus Infectionsupporting

confidence: 68%

“…According to a recently published Russian-language literature review, a number of studies focused on the occurrence of infection in Western Siberia some 20-30 years ago. They showed that O. felineus prevalence exceeded 50% among adults in some Siberian regions, such as Tomsk Oblast, Tyumen Oblast, and Yamal-Nenets and Khanty-Mansiysk autonomous Okrugs [10]. Our results show that present-day O. felineus infection prevalence in Shegarskiy district is still (at least) as high as indicated in previous reports (over 60%).…”

Section: Prevalence Of Opisthorchis Felineus Infectionsupporting

confidence: 57%

“…O. felineus is considered to be zoonotic [1]. Most infections with O. felineus are asymptomatic [10]. Chronic O. felineus infection may lead to any of several severe liver and bile duct diseases, such as cholecystitis, cholangitis, and periductal fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

et al. 2020

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Background The liver fluke, Opisthorchis felineus, is widely distributed throughout Europe and large parts of the Russian Federation. In Western Siberia, information about opisthorchiasis is lacking although infection may lead to severe liver and bile duct diseases. We aimed to assess the current prevalence of O. felineus infection along with associated risk factors and morbidity in rural Western Siberia. Methods We conducted a community-based, cross-sectional study in the rural Shegarskiy district, Tomsk Oblast, Russian Federation. All household members (� 7 years) present on the survey day were enrolled (n = 600). Two stool samples per person were examined for helminth eggs, using PARASEP (DiaSys Ltd, UK). The number of eggs per gram (EPG) of feces was recorded. Each study participant was interviewed to determine risk factors, using a pretested questionnaire. An abdominal ultrasonography examination of liver and bile ducts was performed with a mobile, high resolution ultrasound device. In total, 488 persons completed assessments (two stool samples, completed questionnaires); of those, 436 individuals had an ultrasonography (US) examination. Results We observed a prevalence of O. felineus infection of 60.2%. Significant risk factors for infection were the consumption of river fish (odds ratio from adjusted analysis [aOR] 2.4, 95% CI

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Section: Prevalence Of Opisthorchis Felineus Infectionsupporting

confidence: 68%

Section: Prevalence Of Opisthorchis Felineus Infectionsupporting

confidence: 57%

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Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

et al. 2020

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“…were determined to be 0.05% and 0.04%, respectively, in bile samples from 50 patients undergoing pancreaticoduodenectomy [ 77 ]. Furthermore, bile samples of subjects with opisthorchiasis (bile duct infection by Opisthorchis felineus [ 94 ]) contained higher amounts of Verrucomicrobia (among other phyla) than subjects with gallstone disease without infection of O. felineus [ 93 ]. The presence of Verrucomicrobia was not specific to the Akkermansia genus and the exact relative abundance of Verrucomicrobia was not provided.…”

Section: Akkermansia Muciniphila Along the Humamentioning

confidence: 99%

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

et al. 2018

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Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.

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“…The present study is the second part of our work on the metabolomics of the host response to the O. felineus infection. The "Siberian liver fluke", O. felineus [12] forms a health risk for a population that is similar in size to the population in the endemic region of O. viverrini [13]. It is also known for its cancerogenic properties but remains far less studied.…”

Section: Introductionmentioning

confidence: 99%

Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus)

et al. 2020

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Background Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae. Opisthorchiasis can lead to severe hepatobiliary morbidity and is classified as a carcinogenic agent. Here we investigate the time-resolved metabolic response to Opisthorchis felineus infection in an animal model. Methodology Thirty golden hamsters were divided in three groups: severe infection (50 metacercariae/ hamster), mild infection (15 metacercariae/hamster) and uninfected (vehicle-PBS) groups. Each group consisted of equal number of male and female animals. Plasma samples were collected one day before the infection and then every two weeks up to week 22 after infection. The samples were subjected to 1 H Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate statistical modelling.

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Opisthorchis felineus infection prevalence in Western Siberia: A review of Russian literature

Cited by 29 publications

References 21 publications

Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus)

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