OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C and rs9138 C/A and cancer risk in a Chinese population

Abstract

Previous studies have investigated the association between osteopontin (OPN) gene polymorphisms, rs17524488 (−156 GG/G), rs11730582 (−443 T/C), and rs9138 (C/A) and cancer risk in the Chinese population. However, the results are controversial and indefinite. We therefore carried out a meta-analysis to derive a more precise estimation of these associations. The PubMed database was systematically searched to identify potentially eligible reports. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations between 3 OPN gene polymorphisms and cancer risk in a Chinese population. A total of 10 articles involving 2,391 cases and 3,007 controls were evaluated. The pooled OR indicated that OPN rs17524488 (−156 GG/G) polymorphism was significantly associated with cancer risk in Chinese population. In a stratified analysis by source of control, significant associations were also observed among rs17524488 (−156 GG/G) and rs11730582 (−443 T/C) polymorphisms and cancer. In addition, a stronger association was observed between rs9138 (C/A) polymorphism and cancer risk. In conclusion, this meta-analysis suggests that OPN rs17524488 (−156 GG/G), rs11730582 (−443 T/C), and rs9138 (C/A) polymorphisms may be associated with cancer susceptibility in the Chinese population. Nevertheless, further investigation on a larger population covering different ethnicities are warranted.

Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population

“…So far, genetic variants in the OPN gene have shown being involved in susceptibility to other immune-mediated diseases such as systemic lupus erythematosus [ 19 ], Crohn's disease [ 20 ], rheumatoid arthritis [ 21 ], and lupus nephritis [ 22 ]. In addition, overexpression of OPN has been described in several basic inflammatory processes, such as arthritis [ 23 ], myocardial remodeling after infarction [ 24 ], kidney interstitial fibrosis after obstructive uropathy [ 25 ], wound healing [ 26 ], and several types of cancer [ 27 ], where it is demonstrated that OPN gene polymorphism and OPN levels play important roles in immune- and inflammatory-mediated diseases, including AS.…”

The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis

“…Among the 12 SNPs, 1 tag SNP (rs2853749) was selected using the HapMap database with the software as previously described, and 11 SNPs (rs2728127, rs2853744, rs11730582, rs11439060, rs11728697, rs6840362, rs4754, rs1126616, rs4660, rs1126772, and rs9138) were previously reported (25–33). Ten of these have functional potential (rs2728127, rs2853744, rs11730582, rs11439060 in the 5′ near gene; rs11728697, rs4754, rs1126616, rs4660 in coding region; rs1126772, rs9138 in 3′-untranslated region).…”

“…Twelve SNPs (variations in single base pairs in a DNA sequence) were selected based on previous reports and information from NCBI dbSNP and HapMap database [CHB database, HapMap phase version 3, release 27 (2009, February)], in an attempt to cover the majority of the SPP1 gene region by linkage disequilibrium (LD). Among the 12 SNPs, 1 tag SNP (rs2853749) was selected using the HapMap database with the software as previously described, and 11 SNPs (rs2728127, rs2853744, rs11730582, rs11439060, rs11728697, rs6840362, rs4754, rs1126616, rs4660, rs1126772, and rs9138) were previously reported ( 25 – 33 ). Ten of these have functional potential (rs2728127, rs2853744, rs11730582, rs11439060 in the 5′ near gene; rs11728697, rs4754, rs1126616, rs4660 in coding region; rs1126772, rs9138 in 3′-untranslated region).…”

OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study

“…OPN gene, located at 4q21-25, comprises seven exons and phosphorylated acidic glycoprotein codes in several tissues and cells. The OPN protein function could be affected by some polymorphic variants located in the transcriptional factor binding-site region [13,14]. The rs11730582 is located in the promoter region of OPN gene, which may affect transcriptional activity of OPN.…”